Matsuda Z, Chou M J, Matsuda M, Huang J H, Chen Y M, Redfield R, Mayer K, Essex M, Lee T H
Department of Cancer Biology, Harvard University School of Public Health, Boston, MA 02115.
Proc Natl Acad Sci U S A. 1988 Sep;85(18):6968-72. doi: 10.1073/pnas.85.18.6968.
Eight coding regions designated gag, pol, env, sor, R, tat, art/trs, and 3' orf have been identified in the genome of the human immunodeficiency virus type 1 (HIV-1). Several other open reading frames have the potential to encode additional viral proteins. In this study, we show that HIV-1 has another coding sequence whose product is expressed during natural infection. Unlike antibody to other HIV-1 proteins, the prevalence of antibody to the product encoded by this region is elevated in patients with acquired immune deficiency syndrome (AIDS). Because no analogous coding region has been identified in HIV-2, the antibody to the product of this coding region may serve as a marker to distinguish infection with HIV-1 from infection with HIV-2.
在1型人类免疫缺陷病毒（HIV-1）基因组中已鉴定出八个编码区，分别命名为gag、pol、env、sor、R、tat、art/trs和3' 开放阅读框（orf）。其他几个开放阅读框有可能编码额外的病毒蛋白。在本研究中，我们表明HIV-1有另一个编码序列，其产物在自然感染期间表达。与针对其他HIV-1蛋白的抗体不同，获得性免疫缺陷综合征（AIDS）患者中针对该区域编码产物的抗体流行率升高。由于在HIV-2中未鉴定出类似的编码区，针对该编码区产物的抗体可能作为区分HIV-1感染和HIV-2感染的标志物。
