Genovese Licia, Corbo Andrea, Sibilla Sara
Minerva Research Labs Ltd., London, UK.
Skin Pharmacol Physiol. 2017;30(3):146-158. doi: 10.1159/000464470. Epub 2017 May 20.
Skin aging is a multifactorial phenomenon which causes alterations in skin physiological functions and, most visibly, phenotypic changes. In particular, during the aging process, hyaluronic acid, collagen, and elastin fibers undergo structural and functional changes.
This study aimed to give an insight into the photo-protective benefits and efficacy of an oral liquid nutricosmeceutical containing collagen bioactive peptides and antioxidants to counteract the signs of aging.
A double-blind, randomized, placebo-controlled clinical trial was conducted by an independent esthetic clinic on 120 healthy volunteer subjects for 90 days. Subjects were divided into 2 groups: 60 subjects consumed 1 bottle (50 mL) of the nutricosmeceutical daily and the other 60 consumed 1 bottle (50 mL) of the placebo. Outcome measures were related to skin elasticity (expressed as Young's elasticity modulus) and skin architecture (histological analysis). In addition, the subjects recruited in this study underwent observational assessments through self-assessment questionnaires.
Overall, we demonstrated a significant increase in skin elasticity (+7.5%), p ≤ 0.001 and an improvement in skin texture after daily oral consumption of the nutricosmeceutical. We also obtained a positive patient feedback through the self-assessment questionnaires. Taken together these results show that this nutricosmeceutical supplement may have photo-protective effects and help improve skin health.
皮肤老化是一种多因素现象,会导致皮肤生理功能改变,最明显的是表型变化。特别是在衰老过程中,透明质酸、胶原蛋白和弹性纤维会发生结构和功能变化。
本研究旨在深入了解一种含有胶原蛋白生物活性肽和抗氧化剂的口服营养化妆品口服液对抵抗衰老迹象的光保护益处和功效。
一家独立的美容诊所对120名健康志愿者进行了一项为期90天的双盲、随机、安慰剂对照临床试验。受试者分为两组:60名受试者每天服用1瓶(50毫升)营养化妆品,另外60名受试者每天服用1瓶(50毫升)安慰剂。观察指标与皮肤弹性(以杨氏弹性模量表示)和皮肤结构(组织学分析)有关。此外,本研究招募的受试者通过自我评估问卷进行观察性评估。
总体而言,我们证明每天口服该营养化妆品后,皮肤弹性显著增加(+7.5%),p≤0.001,皮肤质地得到改善。我们还通过自我评估问卷获得了积极的患者反馈。综合这些结果表明,这种营养化妆品补充剂可能具有光保护作用,并有助于改善皮肤健康。