Cristea Cecilia, Tertis Mihaela, Galatus Ramona
Analytical Chemistry Department, Faculty of Pharmacy, Iuliu Haţieganu University of Medicine and Pharmacy, 4 Pasteur St., 400349 Cluj-Napoca, Romania.
Basis of Electronics Department, Faculty of Electronics, Telecommunication and Information Technology, Technical University of Cluj-Napoca, 28 Memorandumului St., 400114 Cluj-Napoca, Romania.
Nanomaterials (Basel). 2017 May 24;7(6):119. doi: 10.3390/nano7060119.
Widespread use of antibiotics has led to pollution of waterways, potentially creating resistance among freshwater bacterial communities. Microorganisms resistant to commonly prescribed antibiotics (superbug) have dramatically increased over the last decades. The presence of antibiotics in waters, in food and beverages in both their un-metabolized and metabolized forms are of interest for humans. This is due to daily exposure in small quantities, that, when accumulated, could lead to development of drug resistance to antibiotics, or multiply the risk of allergic reaction. Conventional analytical methods used to quantify antibiotics are relatively expensive and generally require long analysis time associated with the difficulties to perform field analyses. In this context, electrochemical and optical based sensing devices are of interest, offering great potentials for a broad range of analytical applications. This review will focus on the application of magnetic nanoparticles in the design of different analytical methods, mainly sensors, used for the detection of antibiotics in different matrices (human fluids, the environmental, food and beverages samples).
抗生素的广泛使用导致了水道污染，有可能在淡水细菌群落中产生耐药性。在过去几十年里，对常用抗生素有抗性的微生物（超级细菌）急剧增加。水中、食品和饮料中未代谢和代谢形式的抗生素的存在对人类来说是令人关注的。这是因为日常会少量接触，而这种接触累积起来可能会导致对抗生素产生耐药性，或者增加过敏反应的风险。用于量化抗生素的传统分析方法相对昂贵，并且通常需要较长的分析时间，同时还存在现场分析困难的问题。在这种背景下，基于电化学和光学的传感装置受到关注，它们在广泛的分析应用中具有巨大潜力。本综述将聚焦于磁性纳米颗粒在不同分析方法（主要是传感器）设计中的应用，这些方法用于检测不同基质（人体体液、环境、食品和饮料样品）中的抗生素。
