Bartoloni E, Alunno A, Valentini V, Luccioli F, Valentini E, La Paglia G, Bistoni O, Gerli Roberto
Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy.
High Blood Press Cardiovasc Prev. 2017 Dec;24(4):353-361. doi: 10.1007/s40292-017-0214-3. Epub 2017 Jun 9.
Chronic inflammatory diseases (CID) are characterized by an increased risk of cardiovascular (CV) morbidity and mortality. Several mechanisms, including early acceleration of subclinical atherosclerotic damage, inflammatory markers and immune system deregulation factors, have been demonstrated to strictly interplay for development and progression of atherosclerosis. Moreover, traditional CV risk factors are likely to explain at least some of the excess of CV risk in these patients. Among traditional CV risk factors, compelling evidence suggests a higher incidence and prevalence of hypertension in patients with CID in comparison to the general population. Moreover, hypertension represents an important predictor of CV events in these patients. Pathogenic mechanisms underlying the rise of blood pressure in CID are multifactorial and still poorly investigated. Indeed, multiple disease-related factors may affect blood pressure control in these patients and hypertension may affect disease prognosis and increase CV risk. Better knowledge of the complex interplay between hypertension and CID will be important to elucidate pathogenic mechanisms and to improve CV outcome in these patients. Aim of this review is to highlight available evidence on the relationship between hypertension and CID and to elucidate the multiple factors that may affect blood pressure control in these disorders.
慢性炎症性疾病（CID）的特征是心血管（CV）发病和死亡风险增加。包括亚临床动脉粥样硬化损伤的早期加速、炎症标志物和免疫系统失调因素在内的多种机制，已被证明在动脉粥样硬化的发生和发展过程中密切相互作用。此外，传统的心血管危险因素可能至少部分解释了这些患者心血管风险增加的原因。在传统的心血管危险因素中，有力证据表明，与普通人群相比，CID患者高血压的发病率和患病率更高。此外，高血压是这些患者心血管事件的重要预测指标。CID患者血压升高的致病机制是多因素的，目前仍研究不足。事实上，多种与疾病相关的因素可能影响这些患者的血压控制，而高血压可能影响疾病预后并增加心血管风险。更好地了解高血压与CID之间的复杂相互作用，对于阐明致病机制和改善这些患者的心血管结局至关重要。本综述的目的是强调关于高血压与CID之间关系的现有证据，并阐明可能影响这些疾病血压控制的多种因素。
