Vilanova María Belén, Falguera Mireia, Marsal Josep Ramon, Rubinat Esther, Alcubierre Núria, Castelblanco Esmeralda, Granado-Casas Minerva, Miró Neus, Molló Àngels, Mata-Cases Manel, Franch-Nadal Josep, Mauricio Didac
Primary Health Care Centre Igualada Nord, Consorci Sanitari de l'Anoia, Servei Català de la Salut, Barcelona, Spain.
Unitat de Suport a la Recerca, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Lleida, Spain.
BMJ Open. 2017 Jun 11;7(6):e015158. doi: 10.1136/bmjopen-2016-015158.
The Mollerussa prospective cohort was created to study pre-diabetes in a population-based sample from the primary care setting in the semirural area of Pla d'Urgell in Catalonia (Spain). The aims of the study were to assess the prevalence of pre-diabetes in our population, the likelihood to develop overt diabetes over time and to identify risk factors associated with the progression of the condition.
The cohort includes 594 subjects randomly selected between March 2011 and July 2014 from our primary care population, who were older than 25 years, consented to participate and did not have a recorded diagnosis of diabetes.
At baseline, we performed a clinical interview to collect demographic, clinical and lifestyle (including a nutritional survey) characteristics; carotid ultrasound imaging to assess subclinical cardiovascular disease was also performed, and a blood sample was collected, with an overall <5% rate of missing data. An additional blood draw was performed 12 months after initial recruitment to reassess laboratory results in patients initially identified as having pre-diabetes, with an 89.6% retention rate. Several studies investigating various hypotheses are currently ongoing.
All subjects recruited during the cohort creation will be followed long-term through annual extraction of data from health records stored in the electronic Clinical station in Primary Care database. The Mollerussa cohort will thus be a sound population-based sample for multiple future research projects to generate insights into the epidemiology and natural history of pre-diabetes in Spain.
创建莫勒鲁萨前瞻性队列，以研究西班牙加泰罗尼亚乌尔盖尔平原半农村地区基层医疗环境中基于人群样本的糖尿病前期情况。该研究的目的是评估我们人群中糖尿病前期的患病率、随时间发展为显性糖尿病的可能性，并确定与病情进展相关的危险因素。
该队列包括2011年3月至2014年7月从我们的基层医疗人群中随机选取的594名受试者，他们年龄超过25岁，同意参与且没有糖尿病确诊记录。
在基线时，我们进行了临床访谈以收集人口统计学、临床和生活方式（包括营养调查）特征；还进行了颈动脉超声成像以评估亚临床心血管疾病，并采集了血样，总体缺失数据率<5%。在初次招募12个月后，对最初被确定为患有糖尿病前期的患者再次进行血样采集以重新评估实验室结果，保留率为89.6%。目前正在进行多项研究以调查各种假设。
通过每年从存储在基层医疗数据库电子临床站的健康记录中提取数据，对队列创建期间招募的所有受试者进行长期随访。因此，莫勒鲁萨队列将成为一个可靠的基于人群的样本，用于未来多个研究项目，以深入了解西班牙糖尿病前期的流行病学和自然史。
