伊朗良性和恶性卵巢上皮性肿瘤中HPV的缺失情况。
Lack of HPV in Benign and Malignant Epithelial Ovarian Tumors in Iran.
作者信息
Farzaneh Farah, Nadji Seyed Alireza, Khosravi Donya, Hosseini Maryam Sadat, Hashemi Bahremani Mohammad, Chehrazi Mohammad, Bagheri Ghazal, Sigaroodi Afsaneh, Haghighatian Zahra
机构信息
1. Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email:
出版信息
Asian Pac J Cancer Prev. 2017 May 1;18(5):1233-1236. doi: 10.22034/APJCP.2017.18.5.1233.
Background: Ovarian epithelial tumors one of the most common gynecological neoplasms; we here evaluated the presence of HPV in benign and malignant examples. Methods: In this cross-sectional study the records of 105 patients with epithelial ovarian tumors (benign and malignant) referred to Imam Hossein University Hospital from 2012 to 2015 were evaluated along with assessment of the presence of the HPV infection using PCR. Results: Among 105 patients, comprising 26 (24.8%) with malignant and 79 (75.2%) with benign lesions, the factors found to impact on malignancy were age at diagnosis, age at first pregnancy, number of pregnancies and hormonal status. However, malignancies was not related to abortion, late menopause, and early menarche. In none of the ovarian tissues (benign and malignant) was HPV DNA found. Conclusion: In this study HPV DNA could not be found in any epithelial ovarian tumors (benign and malignant) removed from 105 women; more studies with larger sample size are needed for a definite conclusion.
背景
卵巢上皮性肿瘤是最常见的妇科肿瘤之一；我们在此评估良性和恶性样本中HPV的存在情况。方法：在这项横断面研究中，评估了2012年至2015年转诊至伊玛目侯赛因大学医院的105例上皮性卵巢肿瘤（良性和恶性）患者的记录，并使用PCR评估HPV感染的存在情况。结果：在105例患者中，包括26例（24.8%）恶性病变和79例（75.2%）良性病变，发现影响恶性肿瘤的因素有诊断时年龄、首次怀孕年龄、怀孕次数和激素状态。然而，恶性肿瘤与流产、绝经晚和初潮早无关。在所有卵巢组织（良性和恶性）中均未发现HPV DNA。结论：在本研究中，从105名女性切除的任何上皮性卵巢肿瘤（良性和恶性）中均未发现HPV DNA；需要进行更多样本量更大的研究才能得出明确结论。
Zotero 插件