Yunnan Institute of Digestive Disease, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.
Department of Gastrointestinal Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.
Sci Rep. 2017 Jun 15;7(1):3628. doi: 10.1038/s41598-017-03706-9.
Substance abuse and addiction are worldwide concerns. In China, populated with over 1.3 billion people, emerging studies show a steady increase in substance abuse and substance-related problems. Some of the major challenges include a lack of an effective evaluation platform to determine the health status of substance-addicted subjects. It is known that the intestinal microbiota is associated to the occurrence and development of human diseases. However, the changes of bacterial diversity of intestinal microbiota in substance-addicted subjects have not been clearly characterized. Herein, we examined the composition and diversity of intestinal microbiota in 45 patients with substance use disorders (SUDs) and in 48 healthy controls (HCs). The results show that the observed species diversity index and the abundance of Thauera, Paracoccus, and Prevotella are significantly higher in SUDs compared to HCs. The functional diversity of the putative metagenomes analysis reveals that pathways including translation, DNA replication and repair, and cell growth and death are over-represented while cellular processes and signaling, and metabolism are under-represented in SUDs. Overall, the analyses show that there seem to be changes in the microbiota that are associated with substance use across an array of SUDs, providing fundamental knowledge for future research in substance-addiction assessment tests.
物质滥用和成瘾是全球性问题。在中国，有超过 13 亿人口，新的研究表明，物质滥用和与物质相关的问题呈稳步上升趋势。其中一些主要挑战包括缺乏有效的评估平台来确定物质成瘾者的健康状况。众所周知，肠道微生物群与人类疾病的发生和发展有关。然而，物质成瘾者肠道微生物群的细菌多样性变化尚未得到明确描述。在此，我们研究了 45 名物质使用障碍（SUD）患者和 48 名健康对照者（HC）的肠道微生物群组成和多样性。结果表明，与 HC 相比，SUD 患者的观测物种多样性指数和 Thauera、Paracoccus 和 Prevotella 的丰度显著更高。推测元基因组分析的功能多样性表明，在 SUD 中，翻译、DNA 复制和修复以及细胞生长和死亡等途径被过度表达，而细胞过程和信号以及代谢则被低估。总体而言，这些分析表明，与各种 SUD 相关的物质使用似乎与微生物群的变化有关，为未来物质成瘾评估测试的研究提供了基础知识。
