Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
German Center for Diabetes Research (DZD), Nuthetal, Germany.
Sci Rep. 2017 Jun 16;7(1):3750. doi: 10.1038/s41598-017-03965-6.
Lipidomics have a great potential as clinical tool for monitoring metabolic changes in health and disease. Nevertheless hardly anything is known about the heritability of lipids. Therefore, it is necessary to clarify how and how much we can affect these progresses in individuals. In our interventional twin study (46 healthy, non-obese twin pairs) we investigated the lipid profile in plasma samples after switching from a low fat diet to an isocaloric high fat diet (HFD) to characterize the metabolic adaptation. Additionally we used the ACE model for Additive genetics, Common and unique Environment as well as linear mixed modelling to analyse the heritability of lipids. The heritability of lipids varied between 0-62% and applied to lipid species rather than to lipid classes. Phospholipids showed the highest inheritance. In addition, sex, body mass index (BMI) and age were important modifiers. The lipid profile changed already after one week of HFD and diverged further after 5 weeks of additional HFD. Basal concentrations of specific lipids within phospholipids are strongly inherited and are likely to be associated with heritable disease risks. BMI, sex and age were major modifiers. Nutrition strongly alters specific lipid classes, and has to be controlled in clinical association studies.
脂质组学作为一种监测健康和疾病中代谢变化的临床工具具有巨大的潜力。然而，人们对脂质的遗传性几乎一无所知。因此，有必要阐明我们在个体中可以如何以及在多大程度上影响这些进展。在我们的干预性双胞胎研究（46 对健康、非肥胖的双胞胎）中，我们在从低脂饮食转换为等热量高脂肪饮食（HFD）后，研究了血浆样本中的脂质谱，以表征代谢适应。此外，我们使用 ACE 模型（加性遗传、共同和独特环境以及线性混合建模）来分析脂质的遗传性。脂质的遗传性在 0-62%之间变化，适用于脂质种类，而不是脂质类别。磷脂显示出最高的遗传率。此外，性别、体重指数（BMI）和年龄是重要的修饰因素。在 HFD 治疗一周后，脂质谱就发生了变化，在额外的 HFD 治疗 5 周后进一步分化。特定磷脂内的特定脂质的基础浓度具有很强的遗传性，可能与遗传性疾病风险有关。BMI、性别和年龄是主要的修饰因素。营养强烈改变特定的脂质类别，在临床关联研究中必须加以控制。
