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纳米时代的癌症药物递送:综述与展望(综述)

Cancer drug delivery in the nano era: An overview and perspectives (Review).

作者信息

Li Zhen, Tan Shirui, Li Shuan, Shen Qiang, Wang Kunhua

机构信息

Department of Gastrointestinal and Hernia Surgery, Institute of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, P.R. China.

College of Agricultural Sciences, Yunnan University, Kunming, Yunnan, P.R. China.

出版信息

Oncol Rep. 2017 Aug;38(2):611-624. doi: 10.3892/or.2017.5718. Epub 2017 Jun 14.

Abstract

Nanomaterials are increasingly used as drug carriers for cancer therapy. Nanomaterials also appeal to researchers in the areas of cancer diagnosis and biomarker discovery. Several antitumor nanodrugs are currently being tested in preclinical and clinical trials and show promise in therapeutic and other settings. We review the development of nanomaterial drug carriers, including liposomes, polymer nanoparticles, dendritic polymers, and nanomicelles, for the diagnosis and treatment of various cancers. The prospects of nanomaterials as drug carriers for future clinical applications are also discussed.

摘要

纳米材料越来越多地被用作癌症治疗的药物载体。纳米材料在癌症诊断和生物标志物发现领域也吸引着研究人员。目前有几种抗肿瘤纳米药物正在进行临床前和临床试验,并在治疗及其他方面显示出前景。我们综述了用于各种癌症诊断和治疗的纳米材料药物载体的发展,包括脂质体、聚合物纳米颗粒、树枝状聚合物和纳米胶束。还讨论了纳米材料作为药物载体在未来临床应用中的前景。

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