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利用小鼠多部位电生理记录研究焦虑期间的跨区域交流

Multisite Electrophysiology Recordings in Mice to Study Cross-Regional Communication During Anxiety.

作者信息

Harris Alexander Z, Golder Danielle, Likhtik Ekaterina

机构信息

Department of Psychiatry, Columbia University Medical Center, New York City, New York.

Department of Biological Sciences, Hunter College, CUNY, New York City, New York.

出版信息

Curr Protoc Neurosci. 2017 Jul 5;80:8.40.1-8.40.21. doi: 10.1002/cpns.32.

DOI:10.1002/cpns.32
PMID:28678397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5783183/
Abstract

Recording neural activity in awake, freely moving mice is a powerful and flexible technique for dissecting the neural circuit mechanisms underlying pathological behavior. This unit describes protocols for designing a drive and recording single neurons and local field potentials during anxiety-related paradigms. We also include protocols for integrating pharmacologic and optogenetic means for circuit manipulations, which, when combined with electrophysiological recordings, demonstrate input-specific and cell-specific contributions to circuit-wide activity. We discuss the planning, execution, and troubleshooting of physiology experiments during anxiety-like behavior. © 2017 by John Wiley & Sons, Inc.

摘要

在清醒、自由活动的小鼠中记录神经活动，是剖析病理行为背后神经回路机制的一种强大且灵活的技术。本单元描述了在焦虑相关范式中设计驱动并记录单个神经元和局部场电位的方案。我们还包括了整合药理学和光遗传学手段进行回路操纵的方案，这些手段与电生理记录相结合时，可展示对全回路活动的输入特异性和细胞特异性贡献。我们讨论了在类似焦虑行为期间生理学实验的规划、执行及故障排除。© 2017约翰威立国际出版公司