阿尔茨海默病的植物源：传统波斯医学报告综述。
Botanical Sources for Alzheimer's: A Review on Reports From Traditional Persian Medicine.
机构信息
1 Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
2 Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Am J Alzheimers Dis Other Demen. 2017 Nov;32(7):429-437. doi: 10.1177/1533317517717013. Epub 2017 Jul 6.
Herbal medicines for the treatment of Alzheimer's disease (AD) have attracted considerable attention nowadays. Alzheimer's disease is described in traditional Persian medicine (TPM) by the term Nesyān. In this study, 5 main medicinal medieval Persian manuscripts were reviewed to filter plants reported for the treatment of Nesyān. Databases were searched for related possible mechanisms of action of these medicinal plants. Each herb was searched for along with these keywords: "acetyl and butyryl cholinesterase inhibition," "antioxidant," "anti-inflammatory," and "anti-amyloidogenic." In Total, 44 herbs were used for the treatment of Nesyān; 40 of those were authenticated. Also, 30 plants had at least one of the mechanisms of action that were searched for or related pharmacological functions known for the treatment of AD. In this work, we introduce promising candidates in TPM that could undergo further investigation for identification of their active compounds and clinical validation in the treatment of AD.
如今，用于治疗阿尔茨海默病（AD）的草药引起了相当大的关注。在传统的波斯医学（TPM）中，AD 被称为 Nesyān。在这项研究中，我们对 5 本主要的中世纪波斯医学文献进行了回顾，以筛选出用于治疗 Nesyān 的植物。我们还在数据库中搜索了这些药用植物的相关可能作用机制。我们用以下关键词搜索每一种草药：“乙酰胆碱酯酶和丁酰胆碱酯酶抑制”、“抗氧化剂”、“抗炎”和“抗淀粉样蛋白形成”。总共，有 44 种草药被用于治疗 Nesyān；其中 40 种已经被证实。此外，30 种植物至少具有我们搜索的作用机制之一，或者具有已知的用于治疗 AD 的药理学功能。在这项工作中，我们介绍了 TPM 中具有前景的候选药物，这些药物可能需要进一步研究以确定其活性化合物，并在 AD 的治疗中进行临床验证。
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