Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Division of Environmental and Occupational Health, Jockey Club School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
Sci Rep. 2017 Jul 25;7(1):6395. doi: 10.1038/s41598-017-06813-9.
The aim of the study is to explore the longitudinal association of dietary acrylamide exposure with cognitive performance in Chinese elderly. The analysis was conducted among 2534 non-smoking elderly men and women based on a prospective study, Mr. and Ms. OS Hong Kong. Dietary acrylamide intake was assessed by food frequency questionnaires with data on local food contamination, derived from the first Hong Kong Total Diet Study. Global cognitive function was assessed by Cantonese version of Mini-Mental State Exam (MMSE) at the baseline and the 4 year of follow-up. Multivariable-adjusted linear and logistic regression models were used to assess the associations of dietary acrylamide with MMSE score changes or risk of poor cognition. The results indicated that among men with MMSE ≥ 18, each one SD increase of acrylamide decreased MMSE score by 7.698% (95%CI: -14.943%, -0.452%; p = 0.037). Logistic regression revealed an increased risk of poor cognition (MMSE ≤ 26) in men with HR of 3.356 (1.064~10.591, p = 0.039). The association became non-significance after further adjustment for telomere length. No significant association was observed in women. Dietary acrylamide exposure was associated with a mild cognitive decline or increased risk of poor cognition over a 4-year period in non-smoking Chinese elderly men.
本研究旨在探讨中国老年人饮食中丙烯酰胺暴露与认知表现的纵向关联。该分析基于一项前瞻性研究“OS 先生和女士香港”，在 2534 名不吸烟的老年男女中进行。通过食物频率问卷评估饮食中的丙烯酰胺摄入量，并结合香港首次全膳食研究中有关本地食物污染的数据。在基线和 4 年随访时，使用粤语版简易精神状态检查（MMSE）评估总体认知功能。采用多变量调整的线性和逻辑回归模型评估饮食中丙烯酰胺与 MMSE 评分变化或认知障碍风险之间的关联。结果表明，在 MMSE≥18 的男性中，丙烯酰胺每增加一个标准差，MMSE 评分降低 7.698%（95%CI：-14.943%，-0.452%；p=0.037）。逻辑回归显示，男性认知障碍（MMSE≤26）的风险增加，HR 为 3.356（1.064~10.591，p=0.039）。进一步调整端粒长度后，该关联不再具有统计学意义。在女性中未观察到显著关联。在不吸烟的中国老年男性中，饮食中丙烯酰胺暴露与 4 年内轻度认知衰退或认知障碍风险增加相关。
