Brendryen Håvar, Johansen Ayna, Duckert Fanny, Nesvåg Sverre
The Norwegian Centre for Addiction Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postboks 1039 Blindern, 0315, Oslo, Norway.
Alcohol and Drug Research Western Norway, Stavanger University Hospital, Stavanger, Norway.
Int J Behav Med. 2017 Oct;24(5):768-777. doi: 10.1007/s12529-017-9665-0.
The aim of this study was to compare the effectiveness of a brief and an intensive self-help alcohol intervention and to assess the feasibility of recruiting to such interventions in a workplace setting.
Employees who screened positive for hazardous drinking (n = 85) received online personalized normative feedback and were randomly assigned to one out of two conditions: either they received an e-booklet about the effects of alcohol or they received a self-help intervention comprising 62 web-based, fully automated, and interactive sessions, plus reminder e-mails, and mobile phone text messages (Short Message Service).
Two months after baseline, the responders in the intensive condition drank an average of five to six drinks less per week compared to the responders in the brief condition (B = 5.68, 95% CI = 0.48-10.87, P = .03). There was no significant difference between conditions, using baseline observation carried forward imputation (B = 2.96, 95% CI = -0.50-6.42, P = .09). Six months after baseline, no significant difference was found, neither based on complete cases nor intent-to-treat (B = 1.07, 95% CI = -1.29-3.44, P = .37). Challenges with recruitment are thoroughly reported.
The study supports the feasibility and the safety of use for both brief and intensive Internet-based self-help in an occupational setting. The study may inform future trials, but due to recruitment problems and low statistical power, the findings are inconclusive in terms of the intensive program being more effective than brief intervention alone.
ClinicalTrials.gov Identifier: NCT01931618.
本研究旨在比较简短和强化自助式酒精干预的效果，并评估在工作场所招募参与此类干预措施的可行性。
对有害饮酒筛查呈阳性的员工（n = 85）接受了在线个性化规范反馈，并被随机分配到两种情况之一：要么他们收到一本关于酒精影响的电子书，要么他们接受一项自助干预措施，该措施包括62个基于网络的、全自动的交互式课程，外加提醒电子邮件和手机短信（短消息服务）。
在基线后的两个月，强化组的应答者每周饮酒量比简短组的应答者平均少五到六杯（B = 5.68，95%CI = 0.48 - 10.87，P = 0.03）。使用向前结转基线观察值插补法时，两组之间没有显著差异（B = 2.96，95%CI = -0.50 - 6.42，P = 0.09）。在基线后的六个月，无论是基于完整病例还是意向性分析，均未发现显著差异（B = 1.07，95%CI = -1.29 - 3.44，P = 0.37）。详细报告了招募方面的挑战。
该研究支持在职业环境中使用简短和强化的基于互联网的自助方式的可行性和安全性。该研究可能为未来的试验提供参考，但由于招募问题和统计效力较低，就强化方案是否比单独的简短干预更有效而言，研究结果尚无定论。
ClinicalTrials.gov标识符：NCT01931618。
