Noda Y, Ishikawa K, Sasagawa A, Honjo S, Mori S, Tsujimoto H, Hayami M
Jpn J Cancer Res. 1986 Dec;77(12):1227-34.
Studies were made of the hematologic features of 23 adult African green monkeys (Cercopithecus aethiops) naturally infected with simian T-cell leukemia virus (STLV), which is closely related to human T-cell leukemia virus type I. None of the STLV-infected monkeys showed any clinical signs, but their absolute lymphocyte count and percentage of atypical lymphocytes were significantly higher than those of uninfected monkeys. Three STLV-infected monkeys had especially high percentages of atypical lymphocytes. Most of the atypical lymphocytes were small- or medium-sized lymphocytes with a lobulate or convoluted nucleus, and were very similar to the leukemic cells in human cases of adult T-cell leukemia (ATL), while other atypical cells were large lymphoblastoid cells. Both types of atypical cells were positive for Leu2a and Tac antigens, and expressed STLV antigen after short-term culture. These findings suggested the presence of a preleukemic state in these STLV-infected monkeys similar to that seen in human ATL, and indicated the value of this natural infection system as an animal model of ATL in humans.
对23只自然感染猿猴T细胞白血病病毒（STLV）的成年非洲绿猴（猕猴属埃塞俄比亚种）的血液学特征进行了研究，该病毒与人类I型T细胞白血病病毒密切相关。所有感染STLV的猴子均未表现出任何临床症状，但其绝对淋巴细胞计数和非典型淋巴细胞百分比显著高于未感染的猴子。三只感染STLV的猴子非典型淋巴细胞百分比尤其高。大多数非典型淋巴细胞是具有分叶状或卷曲核的小或中型淋巴细胞，与成人T细胞白血病（ATL）人类病例中的白血病细胞非常相似，而其他非典型细胞是大淋巴母细胞样细胞。这两种类型的非典型细胞对Leu2a和Tac抗原均呈阳性，并在短期培养后表达STLV抗原。这些发现表明，这些感染STLV的猴子存在类似于人类ATL中所见的白血病前期状态，并表明这种自然感染系统作为人类ATL动物模型的价值。
