西西里岛膳食植物雌激素摄入量与前列腺癌风险之间的关联。
Association between dietary phytoestrogens intakes and prostate cancer risk in Sicily.
作者信息
Russo Giorgio I, Di Mauro Marina, Regis Federica, Reale Giulio, Campisi Daniele, Marranzano Marina, Lo Giudice Arturo, Solinas Tatiana, Madonia Massimo, Cimino Sebastiano, Morgia Giuseppe
机构信息
a Urology Section , University of Catania , Catania , Italy.
b Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Section of Hygiene and Preventive Medicine , University of Catania , Catania , Italy.
出版信息
Aging Male. 2018 Mar;21(1):48-54. doi: 10.1080/13685538.2017.1365834. Epub 2017 Aug 17.
OBJECTIVE
In this study we aimed to investigate the association between dietary phytoestrogen consumption and prostate cancer in a sample of southern Italian individuals.
METHODS
A population-based case-control study on the association between prostate cancer and dietary factors was conducted from January 2015 to December 2016 in a single institution of the municipality of Catania, southern Italy (Registration number: 41/2015). A total of 118 histopathological-verified prostate cancer (PCa) cases and a total of 222 controls were collected. Dietary data was collected by using two food frequency questionnaires.
RESULTS
Patients with PCa consumed significantly higher levels of phytoestrogens. Multivariate logistic regression showed that lignans (Q[quartile]4 vs. Q1, OR [odds ratio] = 4.72; p < .05) and specifically, lariciresinol (Q4 vs. Q1, OR = 4.60; p < .05), pinoresinol (Q4 vs. Q1, OR = 5.62; p < .05), matairesinol (Q4 vs. Q1, OR = 3.63; p < .05), secoisolariciresinol (Q4 vs. Q1, OR = 4.10; p < .05) were associated with increased risk of PCa. Furthermore, we found that isoflavones (Q3 vs. Q1, OR = 0.28; p < .05) and specifically, genistein (Q4 vs. Q1, OR = 0.40; p < .05) were associated with reduced risk of PCa.
CONCLUSION
We found of an inverse association between dietary isoflavone intake and PCa, while a positive association was found with lignans intake.
目的
在本研究中，我们旨在调查意大利南部人群样本中膳食植物雌激素摄入量与前列腺癌之间的关联。
方法
2015年1月至2016年12月在意大利南部卡塔尼亚市的一个单一机构进行了一项基于人群的病例对照研究，以探讨前列腺癌与膳食因素之间的关联（注册号：41/2015）。共收集了118例经组织病理学证实的前列腺癌（PCa）病例和222例对照。通过使用两份食物频率问卷收集膳食数据。
结果
PCa患者摄入的植物雌激素水平显著更高。多因素逻辑回归显示，木脂素（四分位数[Q]4与Q1相比，优势比[OR]=4.72；p<0.05），特别是落叶松脂醇（Q4与Q1相比，OR=4.60；p<0.05）、松脂醇（Q4与Q1相比，OR=5.62；p<0.05）、罗汉松脂醇（Q4与Q1相比，OR=3.63；p<0.05）、开环异落叶松脂醇（Q4与Q1相比，OR=4.10；p<0.05）与PCa风险增加相关。此外，我们发现异黄酮（Q3与Q1相比，OR=0.28；p<0.05），特别是染料木黄酮（Q4与Q1相比，OR=0.40；p<0.05）与PCa风险降低相关。
结论
我们发现膳食异黄酮摄入量与PCa之间呈负相关，而与木脂素摄入量呈正相关。
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