• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Ketamine as a possible cause of cirrhosis in a patient with chronic pain.氯胺酮可能是一名慢性疼痛患者肝硬化的病因。
Frontline Gastroenterol. 2014 Jul;5(3):208-210. doi: 10.1136/flgastro-2013-100378. Epub 2013 Dec 10.
2
Ketamine for chronic noncancer pain: concerns regarding toxicity.氯胺酮治疗慢性非癌性疼痛：关于毒性的关注。
Curr Opin Support Palliat Care. 2012 Jun;6(2):183-7. doi: 10.1097/SPC.0b013e328352812c.
3
Cholestasis and biliary dilatation associated with chronic ketamine abuse: a case series.慢性氯胺酮滥用相关的胆汁淤积和胆管扩张：病例系列研究。
Singapore Med J. 2011 Mar;52(3):e52-5.
4
The epidemiology and patterns of acute and chronic toxicity associated with recreational ketamine use.与娱乐性使用氯胺酮相关的急慢性毒性的流行病学及模式。
Emerg Health Threats J. 2011 Apr 15;4:7107. doi: 10.3402/ehtj.v4i0.7107.
5
[Ketamine-associated urological symptoms].[氯胺酮相关的泌尿系统症状]
Ned Tijdschr Geneeskd. 2012;156(10):A4176.
6
[Ketamine is used again by both physicians and addicts].医生和吸毒者都再次使用氯胺酮。
Ugeskr Laeger. 2011 Aug 29;173(35):2123-6.
7
Chronic biliary colic associated with ketamine abuse.与氯胺酮滥用相关的慢性胆绞痛。
Int Med Case Rep J. 2016 Jun 2;9:135-7. doi: 10.2147/IMCRJ.S100648. eCollection 2016.
8
[Bladder pain and urinary tract symptoms as a consequence of ketamine abuse].[氯胺酮滥用导致的膀胱疼痛和尿路症状]
Ugeskr Laeger. 2014 Feb 3;176(3):240-2.
9
The destruction of the lower urinary tract by ketamine abuse: a new syndrome?氯胺酮滥用对下尿路的损害：一种新综合征？
BJU Int. 2008 Dec;102(11):1616-22. doi: 10.1111/j.1464-410X.2008.07920.x. Epub 2008 Aug 1.
10
Ketamine as an adjuvant to opioids for cancer pain.氯胺酮作为阿片类药物治疗癌症疼痛的辅助药物。
Cochrane Database Syst Rev. 2012 Nov 14;11:CD003351. doi: 10.1002/14651858.CD003351.pub2.

引用本文的文献

1
Repeated or Continuous Medically Supervised Ketamine Administration Associated with Hepatobiliary Adverse Events: A Retrospective Case Series.重复或连续的医学监督氯胺酮给药与肝胆不良事件相关：一项回顾性病例系列研究。
Drug Saf. 2021 Dec;44(12):1365-1374. doi: 10.1007/s40264-021-01120-9. Epub 2021 Oct 26.

本文引用的文献

1
Obstructive nephropathy and kidney injury associated with ketamine abuse.与氯胺酮滥用相关的梗阻性肾病和肾损伤。
NDT Plus. 2008 Oct;1(5):310-2. doi: 10.1093/ndtplus/sfn054. Epub 2008 May 21.
2
Long-term ketamine and ketamine plus alcohol treatments produced damages in liver and kidney.长期使用氯胺酮和氯胺酮加酒精治疗会导致肝和肾损伤。
Hum Exp Toxicol. 2012 Sep;31(9):877-86. doi: 10.1177/0960327112436404. Epub 2012 Feb 21.
3
Ketamine-induced biliary dilatation: from Hong Kong to New York.氯胺酮引起的胆道扩张：从香港到纽约。
J Addict Med. 2012 Mar;6(1):89-91. doi: 10.1097/ADM.0b013e3182399216.
4
Ketamine use: a review.氯胺酮的使用：综述。
Addiction. 2012 Jan;107(1):27-38. doi: 10.1111/j.1360-0443.2011.03576.x. Epub 2011 Jul 22.
5
Ketamine hepato-toxicity in chronic pain management: another example of unexpected toxicity or a predicted result from previous clinical and pre-clinical data?
Pain. 2011 Sep;152(9):1946-1947. doi: 10.1016/j.pain.2011.04.031. Epub 2011 May 8.
6
Drug-induced liver injury following a repeated course of ketamine treatment for chronic pain in CRPS type 1 patients: a report of 3 cases.氯胺酮治疗 1 型复杂性区域疼痛综合征慢性疼痛后反复用药导致的药物性肝损伤：3 例报告。
Pain. 2011 Sep;152(9):2173-2178. doi: 10.1016/j.pain.2011.03.026. Epub 2011 May 4.
7
Cholestasis and biliary dilatation associated with chronic ketamine abuse: a case series.慢性氯胺酮滥用相关的胆汁淤积和胆管扩张：病例系列研究。
Singapore Med J. 2011 Mar;52(3):e52-5.
8
Ketamine for the treatment of chronic non-cancer pain.氯胺酮治疗慢性非癌性疼痛。
Expert Opin Pharmacother. 2010 Oct;11(14):2417-29. doi: 10.1517/14656566.2010.515978.
9
Upper gastrointestinal problems in inhalational ketamine abusers.吸入性氯胺酮滥用者的上消化道问题。
J Dig Dis. 2010 Apr;11(2):106-10. doi: 10.1111/j.1751-2980.2010.00424.x.
10
Emergency department presentation of ketamine abusers in Hong Kong: a review of 233 cases.香港氯胺酮滥用者在急诊科的表现：233 例病例回顾。
Hong Kong Med J. 2010 Feb;16(1):6-11.

氯胺酮可能是一名慢性疼痛患者肝硬化的病因。

Ketamine as a possible cause of cirrhosis in a patient with chronic pain.

作者信息

Bevan Roisin, Burke Denis

机构信息

Department of Gastroenterology, South Tyneside District Hospital, South Shields, Tyne and Wear, UK.

Department of Gastroenterology, Cumberland Infirmary, Carlisle, Cumbria, UK.

出版信息

Frontline Gastroenterol. 2014 Jul;5(3):208-210. doi: 10.1136/flgastro-2013-100378. Epub 2013 Dec 10.

DOI:10.1136/flgastro-2013-100378
PMID:28839772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5369745/
Abstract

Ketamine has been typically administered in short-term, few doses in the clinical setting of acute pain. Its hallucinogenic side effects have made it popular as a recreational drug. Reports of urological, biliary and liver abnormalities have been reported, mainly in cases of abuse. It is now increasingly used for chronic pain conditions, and here we report liver abnormalities and ultimately cirrhosis in an adult on regular ketamine for chronic facial pain. Abnormal liver function tests were detected incidentally, and with no other cause for liver disease found, liver biopsy was performed. This showed fibrosis with incomplete cirrhosis.

摘要

氯胺酮通常在急性疼痛的临床环境中短期、少量给药。其致幻副作用使其成为一种受欢迎的消遣性药物。已有关于泌尿系统、胆道和肝脏异常的报告，主要见于滥用病例。现在它越来越多地用于慢性疼痛疾病，在此我们报告一例成年患者因慢性面部疼痛规律使用氯胺酮后出现肝脏异常并最终发展为肝硬化。肝功能检查异常是偶然发现的，且未发现其他肝病病因，遂进行了肝活检。结果显示为伴有不完全肝硬化的纤维化。