Chen Hao, He Juan, Lanzafame Raymond, Stadler Istvan, Hamidi Hamid El, Liu Hui, Celli Jonathan, Hamblin Michael R, Huang Yingying, Oakley Emily, Shafirstein Gal, Chung Ho-Kyoon, Wu Shin-Tson, Dong Yajie
College of Optics and Photonics, University of Central Florida, Orlando, FL, USA., Nanoscience Technology Center, University of Central Florida, Orlando, FL, USA.
College of Optics and Photonics, University of Central Florida, Orlando, FL, USA.
J Soc Inf Disp. 2017 Mar;25(3):177-184. doi: 10.1002/jsid.543. Epub 2017 Apr 10.
While OLEDs have struggled to find a niche lighting application that can fully take advantage of their unique form factors as thin, flexible, lightweight and uniformly large-area luminaire, photomedical researchers have been in search of low-cost, effective illumination devices with such form factors that could facilitate widespread clinical applications of photodynamic therapy (PDT) or photobiomodulation (PBM). Although existing OLEDs with either fluorescent or phosphorescent emitters cannot achieve the required high power density at the right wavelength windows for photomedicine, the recently developed ultrabright and efficient deep red quantum dot light emitting devices (QLEDs) can nicely fit into this niche. Here, we report for the first time the in-vitro study to demonstrate that this QLED-based photomedical approach could increase cell metabolism over control systems for PBM and kill cancerous cells efficiently for PDT. The perspective of developing wavelength-specific, flexible QLEDs for two critical photomedical fields (wound repair and cancer treatment) will be presented with their potential impacts summarized. The work promises to generate flexible QLED-based light sources that could enable the widespread use and clinical acceptance of photomedical strategies including PDT and PBM.
虽然有机发光二极管(OLED)一直在努力寻找一种能充分利用其薄、可弯曲、轻便和大面积均匀发光等独特外形因素的利基照明应用,但光医学研究人员一直在寻找具有这种外形因素的低成本、有效照明设备,以促进光动力疗法(PDT)或光生物调节(PBM)的广泛临床应用。尽管现有的具有荧光或磷光发射体的OLED在光医学所需的正确波长窗口无法实现所需的高功率密度,但最近开发的超亮且高效的深红色量子点发光器件(QLED)能够很好地适应这一利基市场。在此,我们首次报告体外研究,以证明这种基于QLED的光医学方法相对于PBM的控制系统可提高细胞代谢,并能有效地杀死癌细胞用于PDT。将介绍为两个关键光医学领域(伤口修复和癌症治疗)开发波长特定的柔性QLED的前景,并总结其潜在影响。这项工作有望产生基于柔性QLED的光源,从而使包括PDT和PBM在内的光医学策略得到广泛应用和临床认可。