Hoffer Michael E, Balaban Carey, Szczupak Mikhaylo, Buskirk James, Snapp Hillary, Crawford James, Wise Sean, Murphy Sara, Marshall Kathryn, Pelusso Constanza, Knowles Sean, Kiderman Alex
Department of Otolaryngology Miami Florida U.S.A.
Department of Neurological Surgery Miller School of Medicine, University of Miami Miami Florida U.S.A.
Laryngoscope Investig Otolaryngol. 2017 Apr 12;2(4):157-165. doi: 10.1002/lio2.74. eCollection 2017 Aug.
The objective of this work is to examine the outcomes of a set of objective measures for evaluating individuals with minor traumatic brain injury (mTBI) over the sub-acute time period. These methods involve tests of oculomotor, vestibular, and reaction time functions. This work expands upon published work examining these test results at the time of presentation.
This study is a prospective age- and sex-matched controlled study.
The subject group was composed of 106 individuals with mTBI and 300 age- and sex-matched controls without a history of mTBI. All individuals agreeing to participate in the study underwent a battery of oculomotor, vestibular, and reaction time tests (OVRT). Those subjects with mTBI underwent these tests at presentation (within 6 days of injury) and 1 and 2weeks post injury. These outcomes were compared to each other over time as well as to results from the controls that underwent 1 test session.
Six measures from 5 tests can classify the control and mTBI during Session 1 with a true positive rate (sensitivity) of 84.9% and true negative rate (specificity) of 97.0%. Patterns of abnormalities changed over time in the mTBI group and overall normalized in a subset of individuals at the third (final) testing session.
We describe an objective and effective second generation testing algorithm for diagnosing and following the prognosis of mTBI/concussion. This testing paradigm will allow investigators to institute better treatments and provide more accurate return to activity advice.
本研究旨在评估一系列客观测量指标在亚急性期对轻度创伤性脑损伤（mTBI）患者的评估结果。这些方法包括眼动、前庭和反应时间功能测试。本研究在已发表的关于这些测试结果在就诊时的研究基础上进行了拓展。
本研究是一项前瞻性年龄和性别匹配的对照研究。
研究对象包括106例mTBI患者和300例年龄和性别匹配、无mTBI病史的对照者。所有同意参与研究的个体均接受了一系列眼动、前庭和反应时间测试（OVRT）。mTBI患者在就诊时（受伤后6天内）、受伤后1周和2周接受这些测试。将这些结果随时间进行相互比较，并与仅接受一次测试的对照组结果进行比较。
5项测试中的6项指标可在第1阶段区分对照组和mTBI组，真阳性率（敏感性）为84.9%，真阴性率（特异性）为97.0%。mTBI组异常模式随时间变化，在第三次（最后一次）测试时，一部分个体的异常情况总体上恢复正常。
我们描述了一种客观有效的第二代测试算法，用于诊断和跟踪mTBI/脑震荡的预后。这种测试模式将使研究人员能够制定更好的治疗方案，并提供更准确的恢复活动建议。
3级。
