Shapumba Christ W, Knott Michael, Kapewangolo Petrina
Department of Chemistry and Biochemistry, Faculty of Science, University of Namibia, P/Bag 13301, Windhoek, Namibia.
School of Pharmacy, University of Namibia, P/Bag 13301, Windhoek, Namibia.
J Food Sci Technol. 2017 Sep;54(10):3370-3373. doi: 10.1007/s13197-017-2784-4. Epub 2017 Aug 28.
The antioxidant potential of various marine natural products is well documented. The aim of this study was to evaluate the antioxidant potential of a rare halogenated monoterpene, namely; 1,3,4,5,7-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene () for the first time. This compound was isolated from a Namibian red algal species. The antioxidant activity of the compound was evaluated using a series of antioxidant assays, namely; 2,2-diphenyl-1-picryl-hydrazyl radical (DPPH), reducing power, nitric oxide (NO) and hydrogen peroxide (HO). The compound demonstrated remarkable DPPH, NO and HO scavenging activities with IC values of 0.05 ± 0.01, 4.18 ± 0.22 and 5.58 ± 1.11 mM, respectively. The reducing power of the compound increased with an increase in concentration. These results were compared to the absorbance of ascorbic acid, which was used as a standard control in all the antioxidant assays. The results strongly suggest that compound is a promising antioxidant agent with potential commercial applications.
各种海洋天然产物的抗氧化潜力已有充分记载。本研究的目的是首次评估一种罕见的卤代单萜即1,3,4,5,7 - 1 - 溴 - 3,4,8 - 三氯 - 7 -(二氯甲基)- 3 - 甲基辛 - 1,5,7 - 三烯()的抗氧化潜力。该化合物是从纳米比亚红藻物种中分离出来的。使用一系列抗氧化测定法评估该化合物的抗氧化活性,即2,2 - 二苯基 - 1 - 苦基肼自由基(DPPH)、还原能力、一氧化氮(NO)和过氧化氢(HO)。该化合物表现出显著的DPPH、NO和HO清除活性,IC值分别为0.05±0.01、4.18±0.22和5.58±1.11 mM。该化合物的还原能力随浓度增加而增强。将这些结果与用作所有抗氧化测定标准对照的抗坏血酸的吸光度进行比较。结果有力地表明化合物是一种有前景的抗氧化剂,具有潜在的商业应用价值。