Kee Ji-Ye, Hong Seung-Heon
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University , 460 Iksandae-ro, Iksan, Jeonbuk 54538, Republic of Korea.
J Agric Food Chem. 2017 Nov 1;65(43):9443-9452. doi: 10.1021/acs.jafc.7b02965. Epub 2017 Oct 17.
The Arctium lappa seeds (Arctii Fructus) and its major active compound, arctigenin (ARC), are known to have anticancer, antiobesity, antiosteoporosis, and anti-inflammatory activities. However, the effect of Arctii Fructus and ARC on mast cell-mediated allergic inflammation and its associated mechanism have not been elucidated. Therefore, we attempted to investigate the antiallergic activity of Arctii Fructus and ARC on mast cells and experimental mouse models. Arctii Fructus water extract (AFW) or ethanol extract (AFE) and ARC reduced the production of histamine and pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, IL-8, and TNF-α in mast cells. AFW, AFE, and ARC inhibited phosphorylation of MAPKs and NF-κB in activated mast cells. Moreover, IgE-mediated passive cutaneous anaphylaxis and compound 48/80-induced anaphylactic shock were suppressed by AFW, AFE, and ARC administration. These results suggest that Arctii Fructus and ARC are potential therapeutic agents against allergic inflammatory diseases.
牛蒡子及其主要活性化合物牛蒡子苷元（ARC）具有抗癌、抗肥胖、抗骨质疏松和抗炎活性。然而，牛蒡子和ARC对肥大细胞介导的过敏性炎症的影响及其相关机制尚未阐明。因此，我们试图研究牛蒡子和ARC对肥大细胞和实验小鼠模型的抗过敏活性。牛蒡子水提取物（AFW）或乙醇提取物（AFE）以及ARC可减少肥大细胞中组胺和促炎细胞因子如白细胞介素（IL）-1β、IL-6、IL-8和肿瘤坏死因子-α的产生。AFW、AFE和ARC抑制活化肥大细胞中丝裂原活化蛋白激酶（MAPKs）和核因子-κB（NF-κB）的磷酸化。此外，AFW、AFE和ARC给药可抑制IgE介导的被动皮肤过敏反应和化合物48/80诱导的过敏性休克。这些结果表明，牛蒡子和ARC是治疗过敏性炎症疾病的潜在药物。
