MAIT 细胞的难题——人类 MAIT 细胞如何区分黏膜屏障组织中的细菌定植与感染。
The MAIT conundrum - how human MAIT cells distinguish bacterial colonization from infection in mucosal barrier tissues.
机构信息
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Global Health, University of Washington, Seattle, WA 98195, USA.
出版信息
Immunol Lett. 2017 Dec;192:7-11. doi: 10.1016/j.imlet.2017.09.013. Epub 2017 Oct 5.
Abstract
We review the recent human mucosal-associated invariant T (MAIT) cell literature to examine the signals that control MAIT cell activation. We discuss these signals in context of MAIT cell function in mucosal barrier tissues and address how MAIT cells avoid responding to commensal bacteria, while maintaining responsiveness to infections.
摘要
我们回顾了近期有关人类黏膜相关恒定 T（MAIT）细胞的文献，以研究控制 MAIT 细胞激活的信号。我们在黏膜屏障组织中 MAIT 细胞功能的背景下讨论这些信号，并探讨 MAIT 细胞如何避免对共生菌产生反应，同时保持对感染的反应性。
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本文引用的文献
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MAIT cells in infectious diseases.固有淋巴细胞在感染性疾病中的作用。
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How MR1 Presents a Pathogen Metabolic Signature to Mucosal-Associated Invariant T (MAIT) Cells.MR1 如何向黏膜相关不变 T（MAIT）细胞呈递病原体代谢特征。
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Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines.人类 MAIT 细胞对不同微生物和先天细胞因子反应的异质性和亚群多样性的多层次。
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Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations.人体疟疾感染可控导致固有淋巴细胞和固有样淋巴细胞群体发生持久变化。
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MAIT-cells: A tailor-made mate in the ancient battle against infectious diseases?黏膜相关恒定T细胞：在对抗传染病的古老战斗中量身定制的伙伴？
Immunol Lett. 2017 Jul;187:53-60. doi: 10.1016/j.imlet.2017.05.007. Epub 2017 May 16.
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Functionally diverse human T cells recognize non-microbial antigens presented by MR1.功能多样的人类T细胞识别由MR1呈递的非微生物抗原。
Elife. 2017 May 18;6:e24476. doi: 10.7554/eLife.24476.
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Immunology. 2017 Jan;150(1):45-54. doi: 10.1111/imm.12673. Epub 2016 Oct 26.
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