Saglio G, Camaschella C, Giai M, Serra A, Guerrasio A, Peirone B, Gasparini P, Mazza U, Ceppellini R, Biglia N
Dipartimento di Scienze Biomediche e Oncologia Umana, Universitá di Torino, Italy.
Breast Cancer Res Treat. 1988 May;11(2):147-53. doi: 10.1007/BF01805838.
The frequencies of 13 different Ha-ras proto-oncogene alleles have been estimated in 92 breast cancer patients and 60 unaffected individuals. The Ha-ras alleles can be identified using a DNA restriction fragment length polymorphism (RFLP) closely linked to the 3' end of the gene, and are characterized by a different length due to a region of sequences repeated a variable number of times (variable tandem repeats, VTR). The statistical analysis of the data obtained shows that the frequency of alleles ranging between specific length limits is significantly higher in breast cancer patients than in controls. The same applies to specific genotypes bearing the aforementioned alleles. This suggests that the inheritance of these alleles may be associated with an increased risk of developing breast cancer.
在92名乳腺癌患者和60名未受影响个体中，估计了13种不同的Ha-ras原癌基因等位基因的频率。可以使用与该基因3'端紧密连锁的DNA限制性片段长度多态性（RFLP）来识别Ha-ras等位基因，其特征是由于一段序列区域重复次数可变（可变串联重复序列，VTR）而具有不同的长度。对所得数据的统计分析表明，在特定长度限制范围内的等位基因频率在乳腺癌患者中显著高于对照组。携带上述等位基因的特定基因型也是如此。这表明这些等位基因的遗传可能与患乳腺癌风险增加有关。
