III. Medical Clinic and
III. Medical Clinic and.
J Am Soc Nephrol. 2018 Feb;29(2):389-399. doi: 10.1681/ASN.2017060599. Epub 2017 Nov 1.
It has become evident that nonlymphoid tissues are populated by distinct subsets of innate and adaptive lymphocytes that are characterized by minimal exchange with recirculating counterparts. Especially at barrier sites, such as the skin, gut, and lung, these tissue-resident lymphocyte populations are ideally positioned to quickly respond to pathogens and other environmental stimuli. The kidney harbors several classes of innate and innate-like lymphocytes that have been described to contribute to this tissue-resident population in other organs, including innate lymphoid cells, natural killer cells, natural killer T cells, mucosal-associated invariant T cells, and T cells. Additionally, a substantial proportion of the adaptive lymphocytes that are found in the kidney displays a surface phenotype suggestive of tissue residency, such as CD69CD4 T cells. In this review, we summarize recent advances in the understanding of tissue-resident lymphocyte populations, review the available evidence for the existence of these populations in the kidney, and discuss the potential physiologic and pathophysiologic roles thereof in kidney.
很明显，非淋巴组织中存在着独特的先天和适应性淋巴细胞亚群，这些亚群与循环中的对应物的交换很少。特别是在屏障部位，如皮肤、肠道和肺部，这些组织驻留的淋巴细胞群能够迅速对病原体和其他环境刺激做出反应。肾脏中存在几类先天和类似先天的淋巴细胞，它们被描述为有助于其他器官中的组织驻留群体，包括先天淋巴样细胞、自然杀伤细胞、自然杀伤 T 细胞、黏膜相关不变 T 细胞和 T 细胞。此外，在肾脏中发现的相当一部分适应性淋巴细胞表现出表面表型，提示其具有组织驻留性，例如 CD69CD4 T 细胞。在这篇综述中，我们总结了对组织驻留淋巴细胞群体的理解的最新进展，回顾了这些群体在肾脏中存在的证据，并讨论了它们在肾脏中的潜在生理和病理生理作用。
