Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China.
Curr Opin Neurobiol. 2018 Feb;48:97-105. doi: 10.1016/j.conb.2017.11.005. Epub 2017 Dec 1.
The ability of neurons to modify or remodel their synaptic connectivity is critical for the function of neural circuitry throughout the life of an animal. Understanding the mechanisms underlying neuronal structural changes is central to our knowledge of how the nervous system is shaped for complex behaviors and how it further adapts to developmental and environmental demands. Caenorhabditis elegans provides a powerful model for examining developmental processes and for discovering mechanisms controlling neural plasticity. Recent findings have identified conserved themes underlying neural plasticity in development and under environmental stress.
神经元改变或重塑其突触连接的能力对于动物一生中神经回路的功能至关重要。理解神经元结构变化的机制是我们了解神经系统如何为复杂行为塑造以及如何进一步适应发育和环境需求的核心。秀丽隐杆线虫为研究发育过程和发现控制神经可塑性的机制提供了一个强大的模型。最近的发现确定了发育和环境应激下神经可塑性的保守主题。
