Yan Zhuocheng, Pan Taisong, Xue Miaomiao, Chen Changyong, Cui Yan, Yao Guang, Huang Long, Liao Feiyi, Jing Wei, Zhang Hulin, Gao Min, Guo Daqing, Xia Yang, Lin Yuan
State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China (UESTC) Chengdu Sichuan 610054 P. R. China.
Key Laboratory for Neuro Information of Ministry of Education School of Life Science and Technology University of Electronic Science and Technology of China (UESTC) Chengdu Sichuan 610054 P. R. China.
Adv Sci (Weinh). 2017 Jul 31;4(11):1700251. doi: 10.1002/advs.201700251. eCollection 2017 Nov.
Soft neural electrode arrays that are mechanically matched between neural tissues and electrodes offer valuable opportunities for the development of disease diagnose and brain computer interface systems. Here, a thermal release transfer printing method for fabrication of stretchable bioelectronics, such as soft neural electrode arrays, is presented. Due to the large, switchable and irreversible change in adhesion strength of thermal release tape, a low-cost, easy-to-operate, and temperature-controlled transfer printing process can be achieved. The mechanism of this method is analyzed by experiments and fracture-mechanics models. Using the thermal release transfer printing method, a stretchable neural electrode array is fabricated by a sacrificial-layer-free process. The ability of the as-fabricated electrode array to conform different curvilinear surfaces is confirmed by experimental and theoretical studies. High-quality electrocorticography signals of anesthetized rat are collected with the as-fabricated electrode array, which proves good conformal interface between the electrodes and dura mater. The application of the as-fabricated electrode array on detecting the steady-state visual evoked potentials research is also demonstrated by experiments and the results are compared with those detected by stainless-steel screw electrodes.
在神经组织和电极之间实现机械匹配的柔性神经电极阵列，为疾病诊断和脑机接口系统的发展提供了宝贵机遇。本文介绍了一种用于制造柔性生物电子器件（如柔性神经电极阵列）的热释放转移印刷方法。由于热释放胶带的粘附强度存在大的、可切换的和不可逆的变化，因此可以实现低成本、易于操作且可控温的转移印刷工艺。通过实验和断裂力学模型对该方法的机理进行了分析。利用热释放转移印刷方法，通过无牺牲层工艺制造了一种柔性神经电极阵列。实验和理论研究证实了所制造的电极阵列贴合不同曲面的能力。用所制造的电极阵列采集了麻醉大鼠的高质量皮层脑电图信号，这证明了电极与硬脑膜之间具有良好的贴合界面。实验还展示了所制造的电极阵列在检测稳态视觉诱发电位研究中的应用，并将结果与不锈钢螺旋电极检测的结果进行了比较。
