Bonifay Timothée, Douine Maylis, Bonnefoy Clémence, Hurpeau Benoit, Nacher Mathieu, Djossou Félix, Epelboin Loïc
Tropical and Infectious Diseases Department, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana, France.
Centre d'Investigation Clinique Antilles Guyane, Cayenne, French Guiana, France.
Open Forum Infect Dis. 2017 Nov 11;4(4):ofx247. doi: 10.1093/ofid/ofx247. eCollection 2017 Fall.
Since 2013, 3 successive arbovirus outbreaks, dengue (DENV), chikungunya (CHIKV), and Zika virus, have occurred in French Guiana (FG). The primary objective of this study was to describe the socioeconomic indicators of the first patients infected with CHIKV during the outbreak of 2014. The secondary objective was to compare those patients with patient infected by DENV and with the local population.
A monocentric, retrospective, case-control study was conducted in Cayenne hospital in FG comparing a group of patients infected with CHIKV in 2014 with a group infected with DENV in 2013. Children aged less than 15 years and pregnant women were excluded.
A total of 168 CHIKV patients were compared with 168 DENV patients. Factors associated with CHIKV were living in poor neighborhoods (82% vs 44%; odds ratio [OR], 5.81; 95% confidence interval [CI], 3.35-10.2), having a precarious status (54% vs 33%; OR, 2.37; 95% CI, 1.49-3.78), and being born abroad (70% vs 35%; OR, 4.35; 95% CI, 2.69-7.06).
The present results suggest that early in the epidemic, the populations most at risk for CHIKV infection were the most socially vulnerable populations in the poorest neighborhoods, whereas DENV appeared to have affected a richer population and richer areas.
自2013年以来，法属圭亚那（FG）接连发生了3次虫媒病毒疫情，即登革热（DENV）、基孔肯雅热（CHIKV）和寨卡病毒疫情。本研究的主要目的是描述2014年疫情期间首批感染基孔肯雅病毒患者的社会经济指标。次要目的是将这些患者与感染登革热病毒的患者以及当地人群进行比较。
在FG的卡宴医院进行了一项单中心、回顾性病例对照研究，将2014年感染基孔肯雅病毒的一组患者与2013年感染登革热病毒的一组患者进行比较。排除了15岁以下儿童和孕妇。
共对168例基孔肯雅病毒患者和168例登革热病毒患者进行了比较。与基孔肯雅病毒感染相关的因素包括居住在贫困社区（82%对44%；优势比[OR]，5.81；95%置信区间[CI]，3.35 - 10.2）、身份不稳定（54%对33%；OR，2.37；95%CI，1.49 - 3.78）以及出生在国外（70%对35%；OR，4.35；95%CI，2.69 - 7.06）。
目前的结果表明，在疫情早期，感染基孔肯雅病毒风险最高的人群是最贫困社区中社会最脆弱的人群，而登革热病毒似乎影响了更富裕的人群和更富裕的地区。
