线粒体对造血干细胞的调控。
Mitochondrial regulation of hematopoietic stem cells.
机构信息
Columbia Center for Human Development, Columbia University Medical Center, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA; Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
出版信息
Curr Opin Cell Biol. 2017 Dec;49:91-98. doi: 10.1016/j.ceb.2017.12.010. Epub 2018 Jan 5.
Abstract
Hematopoietic stem cells (HSCs) preferentially use glycolysis rather than mitochondrial oxidative phosphorylation for energy production. While glycolysis in HSC is typically viewed as response to a hypoxic bone marrow environment that protects HSC from damaging reactive oxygen species, other interpretations are possible. Furthermore, recent evidence directly supports a critical role for mitochondria in the maintenance and function of HSCs that goes beyond ATP production. Here, we review recent advances in our understanding of metabolism and the role of mitochondria in the biology of HSCs.
摘要
造血干细胞（HSCs）优先利用糖酵解而不是线粒体氧化磷酸化来产生能量。虽然 HSC 中的糖酵解通常被视为对缺氧骨髓环境的反应，这种环境可以保护 HSC 免受有害的活性氧的伤害，但也有其他解释。此外，最近的证据直接支持线粒体在维持和功能方面对 HSCs 的关键作用，而不仅仅是产生 ATP。在这里，我们回顾了我们对代谢和线粒体在 HSCs 生物学中的作用的理解的最新进展。
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