Department of Materials Science and Engineering , Drexel University , Philadelphia , Pennsylvania 19104 , United States.
Bioconjug Chem. 2018 Mar 21;29(3):624-634. doi: 10.1021/acs.bioconjchem.7b00669. Epub 2018 Jan 11.
Cell membrane engineering, including live cell membrane bioconjugation and cell membrane-derived nanomaterials is a highly promising strategy to modulate immune responses for treating diseases. Many cell membrane engineering methods have potential for translation for human clinical use in the near future. In this Topical Review, we summarize the cell membrane conjugation strategies that have been investigated for cancer immunotherapy, the prevention of immune rejection to donor cells and tissues, and the induction of antigen-specific tolerance in autoimmune diseases. Additionally, cell membrane-derived or membrane-coated nanomaterials are an emerging class of nanomaterials that is attracting significant attention in the field of nanomedicine. Some of these nanomaterials have been employed to elicit immune responses against cancer, toxins, and bacteria, although their application in establishing immune tolerance has not been explored. In addition to discussing potential problems, we provide our perspectives for promising future directions.
细胞膜工程，包括活细胞膜生物共轭和细胞膜衍生的纳米材料，是一种很有前途的调节免疫反应的策略，可用于治疗疾病。许多细胞膜工程方法具有在不久的将来转化为人类临床应用的潜力。在这篇专题评论中，我们总结了用于癌症免疫治疗、预防对供体细胞和组织的免疫排斥以及诱导自身免疫性疾病中抗原特异性耐受的细胞膜共轭策略。此外，细胞膜衍生或膜包被的纳米材料是一类新兴的纳米材料，在纳米医学领域引起了广泛关注。其中一些纳米材料已被用于引发针对癌症、毒素和细菌的免疫反应，尽管它们在建立免疫耐受方面的应用尚未得到探索。除了讨论潜在的问题外，我们还为有前途的未来方向提供了我们的观点。
