Jang Yeongseon, Choi Won Tae, Johnson Christopher T, García Andrés J, Singh Preet M, Breedveld Victor, Hess Dennis W, Champion Julie A
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, Georgia 30332, United States.
School of Material Science and Engineering, Georgia Institute of Technology, 500 10th Street, Northwest, Atlanta, Georgia 30332, United States.
ACS Biomater Sci Eng. 2018 Jan 8;4(1):90-97. doi: 10.1021/acsbiomaterials.7b00544. Epub 2017 Dec 12.
Bacterial adhesion to stainless steel 316L (SS316L), which is an alloy typically used in many medical devices and food processing equipment, can cause serious infections along with substantial healthcare costs. This work demonstrates that nanotextured SS316L surfaces produced by electrochemical etching effectively inhibit bacterial adhesion of both Gram-negative and Gram-positive , but exhibit cytocompatibility and no toxicity toward mammalian cells in vitro. Additionally, the electrochemical surface modification on SS316L results in formation of superior passive layer at the surface, improving corrosion resistance. The nanotextured SS316L offers significant potential for medical applications based on the surface structure-induced reduction of bacterial adhesion without use of antibiotic or chemical modifications while providing cytocompatibility and corrosion resistance in physiological conditions.
细菌粘附于316L不锈钢（SS316L），这种合金常用于许多医疗设备和食品加工设备，会导致严重感染并产生高昂的医疗成本。这项研究表明，通过电化学蚀刻制备的纳米纹理化SS316L表面能有效抑制革兰氏阴性菌和革兰氏阳性菌的粘附，且在体外对哺乳动物细胞具有细胞相容性且无毒性。此外，对SS316L进行的电化学表面改性导致在表面形成优质的钝化层，提高了耐腐蚀性。基于表面结构诱导的细菌粘附减少，纳米纹理化SS316L在不使用抗生素或化学改性的情况下，在生理条件下提供细胞相容性和耐腐蚀性，在医疗应用方面具有巨大潜力。
