Istituto Superiore di Sanità, Department of Food Safety, Nutrition and Veterinary Public Health, Viale Regina Elena, 299, 00161, Rome, Italy; University Roma Tre, Department of Sciences, Viale Guglielmo Marconi 446, 00146 Rome, Italy.
KU Leuven, University of Leuven, Rega Institute, Department of Microbiology and Immunology, Herestraat 49, 3000 Leuven, Belgium.
Virus Res. 2018 Mar 15;248:1-4. doi: 10.1016/j.virusres.2018.02.010. Epub 2018 Feb 13.
The near-complete genomic sequences of two hepatitis E virus (HEV) strains, detected from feces of infected pigs, were obtained. Phylogenetic analysis and p-distance comparisons of the complete coding regions showed a close relationship to the French swine strain FR-SHEV3c-like detected in 2006 (p-distance value 0.101), belonging to HEV-3 but not assigned to any known subtype. The three HEV sequences showed, relatively high nucleotide distances (p-distance >0.129) compared to the other defined HEV subtype references and unclassified strains. The HEV classification criteria and the high sequence similarity suggest that these strains can be assigned to a putative novel subtype of genotype 3, HEV-3l.
从感染猪的粪便中检测到两株戊型肝炎病毒 (HEV) 近完整基因组序列。对完整编码区的系统进化分析和 p 距离比较表明，与 2006 年在法国猪中检测到的 FR-SHEV3c 样株（p 距离值为 0.101）密切相关，属于 HEV-3，但不属于任何已知亚型。与其他已定义的 HEV 亚型参考株和未分类株相比，这 3 株 HEV 序列的核苷酸距离相对较高（p 距离>0.129）。HEV 的分类标准和高序列相似性表明，这些株可被归为一个假定的新 3 型基因型的亚型，即 HEV-3l。
