Therapeutics Research Centre, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia.
Department of General Surgery, Changzheng Hospital, The Second Military Medical University, 415S, Fengyang Road, Shanghai, 200003, China.
Theranostics. 2018 Feb 2;8(5):1227-1242. doi: 10.7150/thno.22872. eCollection 2018.
Indocyanine green (ICG) is a near-infrared dye that has been used in the clinic for retinal angiography, and defining cardiovascular and liver function for over 50 years. Recently, there has been an increasing interest in the incorporation of ICG into nanoparticles (NPs) for cancer theranostic applications. Various types of ICG-incorporated NPs have been developed and strategically functionalised to embrace multiple imaging and therapeutic techniques for cancer diagnosis and treatment. This review systematically summaries the biodistribution of various types of ICG-incorporated NPs for the first time, and discusses the principles, opportunities, limitations, and application of ICG-incorporated NPs for cancer theranostics. We believe that ICG-incorporated NPs would be a promising multifunctional theranostic platform in oncology and facilitate significant advancements in this research-active area.
吲哚菁绿（ICG）是一种近红外染料，已经在临床中用于视网膜血管造影，并在过去 50 多年中用于定义心血管和肝功能。最近，人们对将 ICG 纳入纳米粒子（NPs）用于癌症治疗诊断应用越来越感兴趣。已经开发了各种类型的 ICG 纳米粒子，并进行了战略性的功能化，以结合多种成像和治疗技术用于癌症的诊断和治疗。这篇综述首次系统地总结了各种类型的 ICG 纳米粒子的体内分布情况，并讨论了 ICG 纳米粒子在癌症治疗诊断中的应用的原理、机遇、局限性和应用。我们相信，ICG 纳米粒子将成为肿瘤学中一种很有前途的多功能治疗诊断平台，并促进该研究活跃领域的重大进展。
