Yusof Muhammad Fuad Hilmi, Zahari Wafa', Hashim Siti Nurnasihah Md, Osman Zul Faizuddin, Chandra Hamshawagini, Kannan Thirumulu Ponnuraj, Noordin Khairul Bariah Ahmad Amin, Azlina Ahmad
Basic Sciences and Oral Biology Unit, School of Dental Sciences, USM Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
Human Genome Center, School of Medical Sciences, USM Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia.
J Oral Biol Craniofac Res. 2018 Jan-Apr;8(1):48-53. doi: 10.1016/j.jobcr.2017.10.003. Epub 2017 Oct 19.
Manipulation of dental stem cells (DSCs) using current technologies in tissue engineering unveil promising prospect in regenerative medicine. DSCs have shown to possess angiogenic and osteogenic potential in both in vivo and in vitro. Neural crest derived DSCs can successfully be isolated from various dental tissues, exploiting their intrinsic great differentiation potential. In this article, researcher team intent to review the characteristics of DSCs, with focus on their angiogenic and osteogenic differentiation lineage. Clinical data on DSCs are still lacking to prove their restorative abilities despite extensive contemporary literature, warranting research to further validate their application for bone tissue engineering.
利用组织工程中的现有技术对牙干细胞（DSCs）进行操控，在再生医学领域展现出了广阔的前景。DSCs在体内和体外均已显示出具有血管生成和成骨潜力。源自神经嵴的DSCs能够成功地从各种牙组织中分离出来，这得益于它们内在的强大分化潜力。在本文中，研究团队旨在综述DSCs的特性，重点关注其血管生成和成骨分化谱系。尽管当代已有大量文献，但仍缺乏临床数据来证明DSCs的修复能力，因此有必要开展研究以进一步验证其在骨组织工程中的应用。
