Olas Beata, Skalski Bartosz, Ulanowska Karolina
Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.
Front Pharmacol. 2018 Mar 15;9:232. doi: 10.3389/fphar.2018.00232. eCollection 2018.
Various parts of sea buckthorn [ (L.) A. Nelson], particularly the berries, known also as seaberries, or Siberian pineapples, are characterized by a unique composition of bioactive compounds: phenolic compounds, vitamins (especially vitamin C), unsaturated fatty acids, and phytosterols such as beta-sitosterol. These berries, together with the juices, jams, and oils made from them, have a range of beneficial antioxidant, anti-inflammatory, and anticancer effects. This short review discusses whether sea buckthorn may represent a "golden mean" for the treatment of cancers: It has anti-proliferation properties and can induce apoptosis and stimulate the immune system, and sea buckthorn oil counteracts many side effects of chemotherapy by restoring kidney and liver function, increasing appetite, and keeping patients in general good health. Although the anticancer activity of sea buckthorn has been confirmed by many and animal studies, the treatment and prophylactic doses for humans are unknown. Therefore, greater attention should be paid to the development of well-controlled and high-quality clinical experiments in this area.
沙棘[（L.）A.尼尔森]的各个部位，尤其是其果实（也称为沙棘果或西伯利亚菠萝），具有独特的生物活性化合物组成：酚类化合物、维生素（尤其是维生素C）、不饱和脂肪酸以及植物甾醇，如β-谷甾醇。这些果实以及用它们制成的果汁、果酱和油，具有一系列有益的抗氧化、抗炎和抗癌作用。这篇简短的综述探讨了沙棘是否可能是治疗癌症的“中庸之道”：它具有抗增殖特性，可诱导细胞凋亡并刺激免疫系统，沙棘油通过恢复肾脏和肝脏功能、增加食欲并使患者总体保持良好健康状态，抵消化疗的许多副作用。尽管沙棘的抗癌活性已得到许多体外和动物研究的证实，但人类的治疗和预防剂量尚不清楚。因此，应更加关注该领域精心设计和高质量的临床试验的开展。
