Aderibigbe Blessing Atim, Buyana Buhle
Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa.
Pharmaceutics. 2018 Apr 2;10(2):42. doi: 10.3390/pharmaceutics10020042.
Alginate is a biopolymer used in a variety of biomedical applications due to its favourable properties, such as biocompatibility and non-toxicity. It has been particularly attractive in wound healing applications to date. It can be tailored to materials with properties suitable for wound healing. Alginate has been used to prepare different forms of materials for wound dressings, such as hydrogels, films, wafers, foams, nanofibres, and in topical formulations. The wound dressings prepared from alginate are able to absorb excess wound fluid, maintain a physiologically moist environment, and minimize bacterial infections at the wound site. The therapeutic efficacy of these wound dressings is influenced by the ratio of other polymers used in combination with alginate, the nature of cross linkers used, the time of crosslinking, nature of excipients used, the incorporation of nanoparticles, and antibacterial agents. This review provides a comprehensive overview of the different forms of wound dressings containing alginate, in vitro, and in vivo results.
藻酸盐是一种生物聚合物，因其具有生物相容性和无毒等良好特性而被用于多种生物医学应用中。迄今为止，它在伤口愈合应用中特别具有吸引力。它可以被制成具有适合伤口愈合特性的材料。藻酸盐已被用于制备不同形式的伤口敷料材料，如水凝胶、薄膜、薄片、泡沫、纳米纤维，以及局部制剂。由藻酸盐制备的伤口敷料能够吸收多余的伤口渗出液，维持生理湿润环境，并将伤口部位的细菌感染降至最低。这些伤口敷料的治疗效果受到与藻酸盐联合使用的其他聚合物的比例、所用交联剂的性质、交联时间、所用辅料的性质、纳米颗粒的掺入以及抗菌剂的影响。本综述全面概述了含藻酸盐的不同形式的伤口敷料、体外和体内研究结果。
