• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

通用液相色谱方法开发工作流程的实施:在分析植物大麻素和大麻提取物中的应用。

Implementation of a generic liquid chromatographic method development workflow: Application to the analysis of phytocannabinoids and Cannabis sativa extracts.

机构信息

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Rue Michel Servet, 1, 1206 Geneva 4, Switzerland.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Rue Michel Servet, 1, 1206 Geneva 4, Switzerland.

出版信息

J Pharm Biomed Anal. 2018 Jun 5;155:116-124. doi: 10.1016/j.jpba.2018.03.059. Epub 2018 Mar 31.

DOI:10.1016/j.jpba.2018.03.059
PMID:29627728
Abstract

A generic liquid chromatographic method development workflow was developed and successfully applied to the analysis of phytocannabinoids and Cannabis sativa extracts. Our method development procedure consists in four steps: At the end, this method development workflow was performed in less than 4 days and minimizes the costs of the method development in liquid chromatography.

摘要

本研究建立了一种通用的液相色谱方法开发工作流程,并成功应用于植物大麻素和大麻提取物的分析。我们的方法开发程序包括四个步骤:最终,该方法开发工作流程在不到 4 天的时间内完成,最大限度地降低了液相色谱法开发的成本。

相似文献

1
Implementation of a generic liquid chromatographic method development workflow: Application to the analysis of phytocannabinoids and Cannabis sativa extracts.通用液相色谱方法开发工作流程的实施:在分析植物大麻素和大麻提取物中的应用。
J Pharm Biomed Anal. 2018 Jun 5;155:116-124. doi: 10.1016/j.jpba.2018.03.059. Epub 2018 Mar 31.
2
Identification and quantification of cannabinoids in Cannabis sativa L. plants by high performance liquid chromatography-mass spectrometry.采用高效液相色谱-质谱法鉴定和定量分析大麻属植物中的大麻素。
Anal Bioanal Chem. 2014 Nov;406(29):7549-60. doi: 10.1007/s00216-014-8177-x. Epub 2014 Oct 23.
3
Chromatographic characterisation of 11 phytocannabinoids: Quantitative and fit-to-purpose performance as a function of extra-column variance.11 种植物大麻素的色谱特征:作为柱外方差函数的定量和专用性能。
Phytochem Anal. 2018 Sep;29(5):507-515. doi: 10.1002/pca.2761. Epub 2018 Mar 30.
4
Qualitative and quantitative measurement of cannabinoids in cannabis using modified HPLC/DAD method.使用改良的 HPLC/DAD 方法对大麻中的大麻素进行定性和定量测量。
J Pharm Biomed Anal. 2017 Nov 30;146:15-23. doi: 10.1016/j.jpba.2017.07.021. Epub 2017 Aug 10.
5
Determination of Acid and Neutral Cannabinoids in Extracts of Different Strains of Cannabis sativa Using GC-FID.采用 GC-FID 法测定不同品种大麻提取物中的酸性和中性大麻素。
Planta Med. 2018 Mar;84(4):250-259. doi: 10.1055/s-0043-124088. Epub 2017 Dec 13.
6
Cannabis Sativa L.: a comprehensive review on the analytical methodologies for cannabinoids and terpenes characterization.大麻:大麻素和萜烯特征分析方法的综合综述。
J Chromatogr A. 2021 Jan 25;1637:461864. doi: 10.1016/j.chroma.2020.461864. Epub 2020 Dec 30.
7
Quantitative Determination of Cannabinoids in Cannabis and Cannabis Products Using Ultra-High-Performance Supercritical Fluid Chromatography and Diode Array/Mass Spectrometric Detection.使用超高效超临界流体色谱和二极管阵列/质谱检测法定量测定大麻及大麻制品中的大麻素
J Forensic Sci. 2017 May;62(3):602-611. doi: 10.1111/1556-4029.13341. Epub 2016 Dec 13.
8
The Development, Validation, and Application of a UHPLC-HESI-MS Method for the Determination of 17 Cannabinoids in L. Plant Material.建立、验证并应用 UHPLC-HESI-MS 法测定 L. 植物材料中 17 种大麻素
Molecules. 2023 Dec 8;28(24):8008. doi: 10.3390/molecules28248008.
9
Development of a LC/MS/MS method for the analysis of cannabinoids in human EDTA-plasma and urine after small doses of Cannabis sativa extracts.一种用于分析小剂量大麻提取物后人体乙二胺四乙酸血浆和尿液中大麻素的液相色谱-串联质谱法的开发。
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 1;850(1-2):515-22. doi: 10.1016/j.jchromb.2006.12.045. Epub 2007 Jan 11.
10
Detection and Quantification of Cannabinoids in Extracts of Cannabis sativa Roots Using LC-MS/MS.利用 LC-MS/MS 检测和定量分析大麻根提取物中的大麻素。
Planta Med. 2018 Mar;84(4):267-271. doi: 10.1055/s-0044-100798. Epub 2018 Jan 22.

引用本文的文献

1
Continuous Depletion of Tetrahydrocannabinol From Cannabis Extract Through Simulated Moving Bed Chromatography Using Green Mobile Phase.使用绿色流动相通过模拟移动床色谱法持续从大麻提取物中去除四氢大麻酚
J Sep Sci. 2025 May;48(5):e70175. doi: 10.1002/jssc.70175.
2
Biopharmaceutical Analysis by HPLC: Practices and Challenges.高效液相色谱法在生物制药分析中的应用:实践与挑战
Chonnam Med J. 2025 Jan;61(1):19-31. doi: 10.4068/cmj.2025.61.1.19. Epub 2025 Jan 24.
3
Challenges of Extracting and Determining Cannabinoids in Different Matrices.
不同基质中大麻素提取与测定的挑战
Cannabis Cannabinoid Res. 2024 Dec;9(6):1470-1477. doi: 10.1089/can.2024.0087. Epub 2024 Aug 12.
4
The analysis of cannabinoids in cannabis samples by supercritical fluid chromatography and ultra-high-performance liquid chromatography: A comparison study.超临界流体色谱法和超高效液相色谱法分析大麻样品中的大麻素:一项比较研究。
Anal Sci Adv. 2020 Nov 26;2(1-2):2-14. doi: 10.1002/ansa.202000091. eCollection 2021 Feb.
5
The Applicability of Chromatographic Retention Modeling on Chiral Stationary Phases in Reverse-Phase Mode: A Case Study for Ezetimibe and Its Impurities.反相模式下手性固定相色谱保留模型的适用性:以依泽替米贝及其杂质为例。
Int J Mol Sci. 2023 Nov 8;24(22):16097. doi: 10.3390/ijms242216097.
6
Facile determination of natural cannabinoids in cannabis products using a conventional fully porous particle column and isocratic high-performance liquid chromatography with diode-array detector.使用传统的全多孔颗粒柱和配备二极管阵列检测器的等度高效液相色谱法轻松测定大麻产品中的天然大麻素。
Forensic Toxicol. 2022 Jul;40(2):417-421. doi: 10.1007/s11419-022-00630-0. Epub 2022 May 27.
7
Analytical method validation for assay determination of cannabidiol and tetrahydrocannabinol in hemp oil infused products by RP-HPLC.反相高效液相色谱法测定大麻油中大麻二酚和四氢大麻酚含量的分析方法验证。
Sci Rep. 2022 Jul 21;12(1):12453. doi: 10.1038/s41598-022-13737-6.
8
Developing Robust Standardised Analytical Procedures for Cannabinoid Quantification: Laying the Foundations for an Emerging Cannabis-Based Pharmaceutical Industry.开发用于大麻素定量的稳健标准化分析程序:为新兴的大麻基制药行业奠定基础。
Med Cannabis Cannabinoids. 2019 Feb 25;2(1):1-13. doi: 10.1159/000496868. eCollection 2019 Sep.
9
Fast Detection of 10 Cannabinoids by RP-HPLC-UV Method in L.在 L. 中用反相高效液相色谱-紫外检测法快速检测 10 种大麻素
Molecules. 2019 Jun 4;24(11):2113. doi: 10.3390/molecules24112113.