State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, 220 Han Dan Road, Shanghai, 200433, China.
Macromol Biosci. 2018 Aug;18(8):e1800077. doi: 10.1002/mabi.201800077. Epub 2018 Jun 19.
Reflux precipitation polymerization (RPP) represents an effective approach that enables to prepare various types of polymeric nanogels with precise control over the morphology and structure. Owing to facile loading or modification by a variety of functional moieties, rationally designed nanogels pose the possibility to attain a platform for tailoring functional properties that could be widely used for various biomedical applications, such as multifunctional drug delivery, enrichment of functional peptides, separation of specific proteins, as well as detection of circulating tumor cells. This feature article highlights RPP as a promising polymerization strategy that provides access to facile generation of modular nanostructures or multifunctional properties in a diverse range of biomedical applications, proving that RPP has great potential to become one of the most attractive polymerization techniques in polymer chemistry.
反流沉淀聚合（RPP）是一种有效的方法，可以精确控制形态和结构，制备各种类型的聚合物纳米凝胶。由于可以通过各种官能团进行易于加载或修饰，合理设计的纳米凝胶有可能获得用于定制功能特性的平台，这些特性可以广泛用于各种生物医学应用，如多功能药物输送、功能肽的富集、特定蛋白质的分离以及循环肿瘤细胞的检测。本文重点介绍了 RPP 作为一种很有前途的聚合策略，它为在各种生物医学应用中轻松生成模块化纳米结构或多功能特性提供了途径，证明了 RPP 具有成为聚合物化学中最有吸引力的聚合技术之一的巨大潜力。
