Barcik Weronika, Untersmayr Eva, Pali-Schöll Isabella, O'Mahony Liam, Frei Remo
Swiss Institiute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland.
Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Drug Discov Today Dis Models. 2015 Winter;17-18:71-80. doi: 10.1016/j.ddmod.2016.06.003. Epub 2016 Oct 24.
The intestinal immune system is intimately connected with the vast array of microbes present within the gut and the diversity of food components that are consumed daily. The discovery of novel molecular mechanisms, which mediate host-microbe-nutrient communication, have highlighted the important roles played by microbes and dietary factors in influencing mucosal inflammatory and allergic responses. In this review, we summarize the recent important findings in this field, which are important for food allergy and particularly relevant to animal models of food allergy.
肠道免疫系统与肠道内存在的大量微生物以及日常摄入的食物成分的多样性密切相关。介导宿主-微生物-营养物质交流的新分子机制的发现，突出了微生物和饮食因素在影响黏膜炎症和过敏反应中所起的重要作用。在本综述中，我们总结了该领域最近的重要发现，这些发现对食物过敏很重要，尤其与食物过敏的动物模型相关。
