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小鼠E.Tn序列长末端重复序列的逆转录病毒特征

Retroviral characteristics of the long terminal repeat of murine E.Tn sequences.

作者信息

Kaghad M, Maillet L, Brûlet P

出版信息

EMBO J. 1985 Nov;4(11):2911-5. doi: 10.1002/j.1460-2075.1985.tb04022.x.

DOI:10.1002/j.1460-2075.1985.tb04022.x
PMID:2998763
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC554597/
Abstract

E.Tn sequences form a family of long moderately repeated sequences which are abundantly transcribed in the pluripotent cell lineage between day 3.5 and 7.5 of early mouse embryogenesis. The structure of the long terminal repeat (LTR) bordering the E.Tn sequences has been investigated by nucleotide sequencing, primer extension and S1 mapping experiments. This has allowed the identification of U3, R and U5 domains, and of several other structural features all of which are characteristics of retroviral LTRs.

摘要

E.Tn序列构成了一个长的中度重复序列家族，在小鼠早期胚胎发育第3.5天至7.5天的多能细胞谱系中大量转录。通过核苷酸测序、引物延伸和S1作图实验研究了与E.Tn序列相邻的长末端重复序列（LTR）的结构。这使得能够鉴定出U3、R和U5结构域，以及其他几个结构特征，所有这些都是逆转录病毒LTR的特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55dc/554597/cecbadbc5e35/emboj00276-0187-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55dc/554597/00b45b4a759d/emboj00276-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55dc/554597/cecbadbc5e35/emboj00276-0187-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55dc/554597/00b45b4a759d/emboj00276-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55dc/554597/cecbadbc5e35/emboj00276-0187-a.jpg

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Structure, variation and synthesis of retrovirus long terminal repeat.逆转录病毒长末端重复序列的结构、变异与合成
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Interruption of two immunoglobulin heavy-chain switch regions in murine plasmacytoma P3.26Bu4 by insertion of retroviruslike element ETn.逆转录病毒样元件ETn的插入导致小鼠浆细胞瘤P3.26Bu4中两个免疫球蛋白重链开关区域的中断。
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