从用L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）致敏的无反应小鼠的淋巴细胞中提取的免疫抑制因子III。GAT特异性抑制因子的免疫化学特性。
Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) III. Immunochemical properties of the GAT-specific suppressive factor.
作者信息
Theze J, Kapp J A, Benacerraf B
出版信息
J Exp Med. 1977 Apr 1;145(4):839-56. doi: 10.1084/jem.145.4.839.
Abstract
The GAT-specific suppressor T-cell factor (GAT-TsF) extracted from lymphoid cells from GAT-primed, nonresponder DBA/1 mice has been partially characterized. It is a protein that has affinity for GAT and determinants encoded by the I region of the H-2 complex. On the basis of specificity and avidity, GAT-TsF resembles anti-GAT-MBSA antibodies produced by DBA/1 mice in spite of the fact that it is too small to be classical antibody and has no constant-region determinants of heavy or light chains. Further, GAT or a fragment of GAT is associated with the GAT-TsF. GAT-TsF has been partially purified from the crude extract by absorption to GAT-Sepharose and elution with 0.4 to 0.6 KCl. GAT-TsF purified on the basis of its affinity for GAT bears I-region determinants but not detectable GAT or GAT fragment.
摘要
从经甘氨酰-丙氨酰-酪氨酸（GAT）致敏的无反应性DBA/1小鼠的淋巴细胞中提取的GAT特异性抑制性T细胞因子（GAT-TsF）已得到部分特性鉴定。它是一种对GAT以及由H-2复合体I区编码的决定簇具有亲和力的蛋白质。基于特异性和亲和力，GAT-TsF类似于DBA/1小鼠产生的抗GAT-甲基牛血清白蛋白（MBSA）抗体，尽管它太小而不是经典抗体，并且没有重链或轻链的恒定区决定簇。此外，GAT或GAT的一个片段与GAT-TsF相关联。通过用GAT-琼脂糖吸附并以0.4至0.6KCl洗脱，已从粗提物中部分纯化了GAT-TsF。基于其对GAT的亲和力纯化的GAT-TsF带有I区决定簇，但未检测到GAT或GAT片段。
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Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) III. Immunochemical properties of the GAT-specific suppressive factor.从用L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）致敏的无反应小鼠的淋巴细胞中提取的免疫抑制因子III。GAT特异性抑制因子的免疫化学特性。
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