Department of general surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Mol Cancer. 2018 Sep 20;17(1):137. doi: 10.1186/s12943-018-0888-8.
CircRNA expression profiles for gastric cancer (GC) were screened using plasma samples from 10 GC patients with different TNM stages and 5 healthy individuals as controls. Results showed lower expression of circ-KIAA1244 in GC tissues, plasmas, and cells compare to normal controls. Further clinical data analysis demonstrated that a decreased expression of circ-KIAA1244 in plasmas was negatively correlated with TNM stage and lymphatic metastasis, and a shorter overall survival time of GC patients. Moreover, we found that circ-KIAA1244 could be detected in GC plasma exosomes and showed no obvious significance compared to the expression level in the corresponding plasmas. This study revealed a GC-tissues-derived circ-KIAA1244 could serve a novel circulating biomarker for detection of GC.
采用 10 例不同 TNM 分期的胃癌患者和 5 例健康对照者的血浆样本，筛选胃癌的环状 RNA 表达谱。结果显示，GC 组织、血浆和细胞中的 circ-KIAA1244 表达水平均低于正常对照组。进一步的临床数据分析表明，血浆中 circ-KIAA1244 的表达水平降低与 TNM 分期和淋巴转移呈负相关，GC 患者的总生存时间更短。此外，我们发现 circ-KIAA1244 可在 GC 血浆外泌体中检测到，与相应血浆中的表达水平相比无明显差异。本研究揭示了源自胃癌组织的 circ-KIAA1244 可作为一种新型循环生物标志物用于胃癌的检测。
