Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan.
Faculty of Medicine and Graduate Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Exp Dermatol. 2018 Dec;27(12):1336-1343. doi: 10.1111/exd.13786. Epub 2018 Oct 22.
The intestinal microbiota has been known to involve in obesity and host immune response. We aimed to investigate the intestinal microbiota and potential genetic function in relation to clinical presentation in psoriasis patients.
Faecal microbiota and predicted genetic function inferred from high-throughput 16S ribosomal RNA sequencing were analysed between psoriasis (n = 32) and age-, gender- and body mass index (BMI)-matched non-psoriasis subjects (n = 64), from a referral medical centre. The correlation between altered microbiota and disease activity, arthritis and systemic anti-psoriatic drugs was also investigated.
We observed a distinct faecal microbial community structure in psoriasis patients, with an increased abundance of phylum Firmicutes and decreased abundance of phylum Bacteroidetes, across different subgroup of subjects. Ruminococcus and Megasphaera, of the phylum Firmicutes, were the top-two genera of discriminant abundance in psoriasis. A number of functional genes and metabolic pathways involving bacterial chemotaxis and carbohydrate transport were predicted over-represented, whereas genes related to cobalamin and iron transport were predicted under-represented in faecal microbiota of psoriasis patients.
The distinct faecal microbial composition in psoriasis might be associated with altered transport of carbohydrate, cobalamin and iron, as well as chemotaxis.
肠道微生物群与肥胖和宿主免疫反应有关。我们旨在研究与银屑病患者临床表现相关的肠道微生物群及其潜在的遗传功能。
从一家转诊医疗中心，分析了银屑病（n=32）和年龄、性别和体重指数（BMI）匹配的非银屑病受试者（n=64）之间的粪便微生物群和高通量 16S 核糖体 RNA 测序推断的潜在遗传功能。还研究了改变的微生物群与疾病活动、关节炎和全身性抗银屑病药物之间的相关性。
我们观察到银屑病患者粪便微生物群落结构明显不同，不同亚组的厚壁菌门丰度增加，拟杆菌门丰度降低。厚壁菌门的瘤胃球菌属和巨球形菌属是银屑病中判别丰度最高的两个属。预测粪便微生物群中存在大量涉及细菌趋化性和碳水化合物运输的功能基因和代谢途径，而与钴胺素和铁运输相关的基因则预测不足。
银屑病中明显的粪便微生物组成可能与碳水化合物、钴胺素和铁的转运以及趋化性改变有关。
