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1980 - 1984年伦敦某卫生区的人类免疫缺陷病毒(HIV)和巨细胞病毒感染情况

Infection with human immunodeficiency virus (HIV) and cytomegalovirus in a London health district 1980-4.

作者信息

Ross M G, Burns D M, Grundy J E, Griffiths P D

出版信息

Genitourin Med. 1987 Feb;63(1):28-31. doi: 10.1136/sti.63.1.28.

DOI:10.1136/sti.63.1.28
PMID:3028935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1194003/
Abstract

By testing serum samples taken between 1980 and 1984 from men attending a department of sexually transmitted diseases, it was shown that antibodies to human immunodeficiency virus (HIV) first appeared in 1981. Homosexual men were significantly more likely to have antibodies to HIV and to cytomegalovirus (CMV) than were heterosexual men attending the same clinic. This shows that homosexuals are exposed to both HIV, the cause of the acquired immune deficiency syndrome (AIDS), and to CMV, which can reactivate to cause life threatening disease once immunosuppression has developed. All homosexuals, not just those with antibodies against HIV, had raised levels of CMV antibodies. This suggests that they experience frequent antigenic stimulation after reinfections with CMV or reactivation of endogenous virus.

摘要

通过检测1980年至1984年间从一家性病科就诊男性身上采集的血清样本,结果显示人类免疫缺陷病毒(HIV)抗体于1981年首次出现。与在同一家诊所就诊的异性恋男性相比,同性恋男性感染HIV和巨细胞病毒(CMV)抗体的可能性显著更高。这表明同性恋者既接触到了获得性免疫缺陷综合征(AIDS)的病因HIV,也接触到了CMV,一旦发生免疫抑制,CMV可重新激活并引发危及生命的疾病。所有同性恋者,不仅仅是那些具有抗HIV抗体的人,其CMV抗体水平都有所升高。这表明他们在CMV再次感染或内源性病毒重新激活后经历了频繁的抗原刺激。

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本文引用的文献

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Retroviruses linked with AIDS.
Nature. 1984;309(5963):12-3. doi: 10.1038/309012a0.
2
Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS.艾滋病患者血清中与人类嗜T淋巴细胞逆转录病毒(HTLV - III)反应的抗体。
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Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).从一名有获得性免疫缺陷综合征(艾滋病)风险的患者体内分离出一种嗜T淋巴细胞逆转录病毒。
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Prevalence of antibody to human T-lymphotropic virus type III in AIDS and AIDS-risk patients in Britain.英国艾滋病患者及艾滋病高危人群中抗人类Ⅲ型嗜T淋巴细胞病毒抗体的流行情况。
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