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老年人生存前沿的推进。

Advancing front of old-age human survival.

机构信息

Department of Biology, Stanford University, Stanford, CA 94040.

School of Sociology, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China.

出版信息

Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):11209-11214. doi: 10.1073/pnas.1812337115. Epub 2018 Oct 16.

Abstract

Old-age mortality decline has driven recent increases in lifespans, but there is no agreement about trends in the age pattern of old-age deaths. Some argue that old-age deaths should become compressed at advanced ages, others argue that old-age deaths should become more dispersed with age, and yet others argue that old-age deaths are consistent with little change in dispersion. However, direct analysis of old-age deaths presents unusual challenges: Death rates at the oldest ages are always noisy, published life tables must assume an asymptotic age pattern of deaths, and the definition of "old-age" changes as lives lengthen. Here we use robust percentile-based methods to overcome some of these challenges and show, for five decades in 20 developed countries, that old-age survival follows an advancing front, like a traveling wave. The front lies between the 25th and 90th percentiles of old-age deaths, advancing with nearly constant long-term shape but annual fluctuations in speed. The existence of this front leads to several predictions that we verify, e.g., that advances in life expectancy at age 65 y are highly correlated with the advance of the 25th percentile, but not with distances between higher percentiles. Our unexpected result has implications for biological hypotheses about human aging and for future mortality change.

摘要

老年死亡率的下降导致了最近寿命的延长,但对于老年死亡的年龄模式趋势,人们并没有达成一致意见。一些人认为老年死亡应该在高龄时变得更加集中,另一些人则认为老年死亡应该随着年龄的增长而更加分散,还有一些人则认为老年死亡与分散度变化不大是一致的。然而,直接分析老年死亡会带来一些特殊的挑战:最年长年龄的死亡率总是不稳定的,出版的生命表必须假设死亡的渐近年龄模式,并且“老年”的定义随着寿命的延长而发生变化。在这里,我们使用基于稳健百分位数的方法来克服其中的一些挑战,并展示了在 20 个发达国家的五个十年中,老年生存遵循一个前进的前沿,就像一个传播波。前沿位于老年死亡的第 25 个和第 90 个百分位数之间,以几乎恒定的长期形状前进,但每年的速度波动。这个前沿的存在导致了一些我们验证的预测,例如,65 岁时预期寿命的提高与第 25 个百分位数的提高高度相关,但与更高百分位数之间的距离无关。我们意想不到的结果对人类衰老的生物学假说和未来的死亡率变化都有影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9233/6217443/bc9c5a9f4eda/pnas.1812337115fig01.jpg

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