Prevention and Control of Infection Administration, King Saud Medical City, Ministry of Health, Riyadh, Saudi Arabia; Department of Family & Community Medicine, College of Medicine and King Khaled Hospital, King Saud University, Riyadh, Saudi Arabia.
Field Epidemiology Training Program (FETP), Department of Public Health, Ministry of Health, Riyadh, Saudi Arabia.
J Infect Public Health. 2019 Mar-Apr;12(2):171-177. doi: 10.1016/j.jiph.2018.09.008. Epub 2018 Oct 16.
MERS-CoV emerged as a zoonotic disease in Saudi Arabia with 1437 cases as of July 2016. This study aimed at describing the epidemiology of MERS-CoV infection, clinical aspects of the disease and the determinants of survival.
The medical records of Prince Mohamed Bin Abdulaziz Hospital were reviewed between April 2014 and December 2015 to identify admission and discharge with MERS-CoV. Patient's characteristics, epidemiologic and clinical data and laboratory results were extracted and described. Logistic regression analyses were used to model the determinants of the survival of these patients. Significance of the results were judged at the 5% level.
249 confirmed cases were admitted mostly in August (20.48%) and September (14.86%) of the year 2015. A third (39.36%) reported contact with an index case, developed the disease after 6.2days and continued to shed the virus for 13.17days on average. The case fatality rate was 20.08%. Independent predictors of being discharged alive among confirmed cases were younger age (OR=0.953), breathing ambient air (OR=8.981), not being transferred to the ICU (OR=24.240) and not receiving renal replacement therapy (OR=8.342). These variables explain 63.9% of the variability of patients' status at discharge.
MERS-CoV spread from human-to-human as community acquired and nosocomial infection. The study identified high risk patients in need for special medical attention in order to improve patients' outcome.
截至 2016 年 7 月，MERS-CoV 作为一种人畜共患病在沙特阿拉伯出现，已有 1437 例病例。本研究旨在描述 MERS-CoV 感染的流行病学、疾病的临床特征和生存的决定因素。
回顾 2014 年 4 月至 2015 年 12 月期间王子穆罕默德·本·阿卜杜勒阿齐兹医院的病历，以确定 MERS-CoV 感染的入院和出院情况。提取并描述患者的特征、流行病学和临床数据以及实验室结果。使用逻辑回归分析来建立这些患者生存的决定因素模型。结果的显著性判断水平为 5%。
2015 年 8 月（20.48%）和 9 月（14.86%）收治了 249 例确诊病例。三分之一（39.36%）报告与指数病例接触，发病后 6.2 天，平均继续排出病毒 13.17 天。病死率为 20.08%。确诊病例中存活出院的独立预测因素是年龄较小（OR=0.953）、呼吸环境空气（OR=8.981）、未转入 ICU（OR=24.240）和未接受肾脏替代治疗（OR=8.342）。这些变量解释了患者出院时状态的 63.9%的变异性。
MERS-CoV 作为社区获得性和医院获得性感染在人与人之间传播。本研究确定了需要特别医疗关注的高危患者，以改善患者的预后。
