Department of Nutritional Science and Food Management, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, Korea.
Department of Integrated Biomedical and Life Sciences, Korea University, Seoul 02841, Korea.
Nutrients. 2018 Oct 23;10(11):1567. doi: 10.3390/nu10111567.
Ginger is a plant whose rhizome is used as a spice or folk medicine. We aimed to investigate the effect of ginger root extract on obesity and inflammation in rats fed a high-fat diet. Sprague-Dawley rats were divided into three groups and fed either a 45% high-fat diet (HF), HF + hot-water extract of ginger (WEG; 8 g/kg diet), or HF + high-hydrostatic pressure extract of ginger (HPG; 8 g/kg diet) for 10 weeks. The HPG group had lower body weight and white adipose tissue (WAT) mass compared to the HF group. Serum and hepatic lipid levels of HPG group were lower, while fecal lipid excretion of the HPG group was higher than that of the HF group. In the WAT of the WEG and HPG groups, mRNA levels of adipogenic genes were lower than those of the HF group. Moreover, HPG group had lower mRNA levels of pro-inflammatory cytokines than did the HF group. MicroRNA (miR)-21 expression was down-regulated by both WEG and HPG. Additionally, miR-132 expression was down-regulated by HPG. The adenosine monophosphate-activated protein kinase (AMPK) activity of HPG group was greater than that of the HF group. HPG may have beneficial effects on obesity and inflammation, partially mediated by regulation of miR-21/132 expression and AMPK activation in WAT.
生姜是一种根茎被用作香料或民间药物的植物。我们旨在研究生姜根提取物对高脂肪饮食喂养大鼠肥胖和炎症的影响。Sprague-Dawley 大鼠分为三组，分别喂食 45%高脂肪饮食（HF）、HF+生姜热水提取物（WEG；8 g/kg 饮食）或 HF+生姜高静压提取物（HPG；8 g/kg 饮食）10 周。与 HF 组相比，HPG 组的体重和白色脂肪组织（WAT）质量较低。HPG 组血清和肝脂质水平较低，而 HPG 组粪便脂质排泄量高于 HF 组。在 WEG 和 HPG 组的 WAT 中，脂肪生成基因的 mRNA 水平低于 HF 组。此外，HPG 组促炎细胞因子的 mRNA 水平低于 HF 组。miR-21 的表达被 WEG 和 HPG 下调。此外，HPG 下调了 miR-132 的表达。HPG 组的一磷酸腺苷激活蛋白激酶（AMPK）活性大于 HF 组。HPG 可能通过调节 WAT 中 miR-21/132 的表达和 AMPK 的激活对肥胖和炎症产生有益影响。
