从深海放线菌 M-169 的培养物中分离得到的一种强力抗革兰氏阳性菌抗生素——蒽环霉素 B。
Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete M-169.
机构信息
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda. del Conocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain.
Departamento de Biología Funcional, Área de Microbiología, and Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain.
出版信息
Mar Drugs. 2018 Oct 25;16(11):406. doi: 10.3390/md16110406.
The potent antimicrobial extract of a culture of the marine derived actinomycete M-169 was fractionated by reversed phase flash chromatography and preparative HPLC to yield the new Gram-positive antibiotic, anthracimycin B (), together with its congener, anthracimycin (). The structure of the new compound was established by analysis of its ESI-TOF MS and 1D and 2D NMR spectra, and comparison with data published for anthracimycin and anthracimycin BII-2619 (). Notably, anthracimycin seemed to be the major and almost unique component of the extract detected by HPLC-UV-MS, making our strain an excellent candidate for further biosynthetic studies of this potent antibiotic.
海洋来源放线菌 M-169 的培养物具有很强的抗菌提取物经反相闪式色谱和制备 HPLC 分离，得到新型革兰氏阳性抗生素，蒽环霉素 B()，以及它的同系物，蒽环霉素()。通过分析其 ESI-TOF MS 和 1D 和 2D NMR 谱，并与蒽环霉素和蒽环霉素 BII-2619 的发表数据进行比较，确定了新化合物的结构()。值得注意的是，蒽环霉素似乎是通过 HPLC-UV-MS 检测到的提取物中的主要成分，几乎是唯一的成分，这使得我们的菌株成为进一步研究这种强效抗生素生物合成的优秀候选菌株。
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