Liu Yuan, He Weilue, Zhang Zhongtian, Lee Bruce P
Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA 01003, USA.
FM Wound Care LLC, Hancock, MI 49930, USA.
Gels. 2018 May 22;4(2):46. doi: 10.3390/gels4020046.
A hydrogel is a three-dimensional polymer network with high water content and has been attractive for many biomedical applications due to its excellent biocompatibility. However, classic hydrogels are mechanically weak and unsuitable for most physiological load-bearing situations. Thus, the development of tough hydrogels used in the biomedical field becomes critical. This work reviews various strategies to fabricate tough hydrogels with the introduction of non-covalent bonds and the construction of stretchable polymer networks and interpenetrated networks, such as the so-called double-network hydrogel. Additionally, the design of tough hydrogels for tissue adhesive, tissue engineering, and soft actuators is reviewed.
水凝胶是一种具有高含水量的三维聚合物网络，由于其优异的生物相容性，在许多生物医学应用中具有吸引力。然而，传统水凝胶的机械性能较弱，不适用于大多数生理承重情况。因此，开发用于生物医学领域的坚韧水凝胶变得至关重要。本文综述了通过引入非共价键以及构建可拉伸聚合物网络和互穿网络（如所谓的双网络水凝胶）来制备坚韧水凝胶的各种策略。此外，还综述了用于组织粘附、组织工程和软致动器的坚韧水凝胶的设计。
