抗菌光动力疗法：控制细菌感染的一种有效替代方法。
Antimicrobial Photodynamic Therapy: An Effective Alternative Approach to Control Bacterial Infections.
作者信息
Mahmoudi Hassan, Bahador Abbas, Pourhajibagher Maryam, Alikhani Mohammad Yousef
机构信息
Microbiology Department, Hamadan University of Medical Sciences, Hamadan, Iran.
Microbiology Department, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
J Lasers Med Sci. 2018 Summer;9(3):154-160. doi: 10.15171/jlms.2018.29. Epub 2018 Jul 28.
Abstract
The purpose of this review was to evaluate the available literature for in vitro and in vivo effectiveness of antimicrobial Photodynamic therapy (aPDT) in the field of bacteriology. A review of the relevant articles carried out in PubMed and Scopus to determine the efficiency of aPDT used in the reduction of microbial infection. Thirty-one relevant documents retrieved from PubMed, Scopus by inserting "antimicrobial photodynamic therapy" and "bacterial infection" and "photodynamic therapy" keywords. According to different results, aPDT can be used as an adjuvant for the treatment of infectious diseases. The use of photosensitizer methylene blue, toluidine blue O (TBO), indocyanine green with light diode laser centered at (630±10 nm) and (650±10 nm) wavelengths have been shown to have significant results for the treatment of infectious diseases and bactericidal properties These findings suggest that, aPDT can be an efficient method in the treatment of localized and superficial infections.
摘要
本综述的目的是评估抗菌光动力疗法（aPDT）在细菌学领域的体外和体内有效性的现有文献。对PubMed和Scopus上的相关文章进行综述，以确定aPDT在减少微生物感染方面的效率。通过插入“抗菌光动力疗法”、“细菌感染”和“光动力疗法”关键词，从PubMed、Scopus检索到31篇相关文献。根据不同结果，aPDT可作为治疗传染病的辅助手段。使用光敏剂亚甲蓝、甲苯胺蓝O（TBO）、吲哚菁绿以及以（630±10 nm）和（650±10 nm）波长为中心的二极管激光，已显示出对治疗传染病和杀菌特性有显著效果。这些发现表明，aPDT可以成为治疗局部和浅表感染的有效方法。
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