Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, D-69120 Heidelberg, Germany.
Faculty of Pharmaceutical Science, Federal University of Amazonas (UFAM), 6200 General Rodrigo, Manaus 69077-000, Brazil.
Molecules. 2019 Mar 6;24(5):915. doi: 10.3390/molecules24050915.
(Huber) Cuatrec (Humiriaceae), known as uxi or uxi-amarelo in Brazil, is an endemic tree of the Amazon forest. In traditional medicine, its stem bark is used to treat a variety of health disorders, including cancer, diabetes, arthritis, uterine inflammation, and gynecological infections. According to HPLC analysis, the main constituent of the bark extract is the polyphenol bergenin. In the current study, we demonstrate by in vitro and in vivo experiments the antioxidant potential of a water extract from the stem bark of . When tested in the model organism the extract enhanced stress resistance via the DAF-16/FOXO pathway. Additionally, the extract promoted an increase in the lifespan of the worms independent from caloric restriction. It also attenuated the age-related muscle function decline and formation of polyQ40 plaques, as a model for Huntington's disease. Thus, these data support anti-aging and anti-oxidant properties of , which has not yet been described. More studies are needed to assess the real benefits of bark for human health and its toxicological profile.
(Huber)Cuatrec（Humiriaceae），在巴西被称为uxi 或 uxi-amarelo，是亚马逊森林的特有树种。在传统医学中，其茎皮用于治疗多种健康障碍，包括癌症、糖尿病、关节炎、子宫炎症和妇科感染。根据 HPLC 分析，树皮提取物的主要成分是多酚 Bergenin。在目前的研究中，我们通过体外和体内实验证明了水提物的抗氧化潜力。在模式生物秀丽隐杆线虫中，提取物通过 DAF-16/FOXO 通路增强了对压力的抵抗力。此外，提取物还能促进线虫的寿命延长，而不依赖于热量限制。它还能减轻与年龄相关的肌肉功能下降和聚 Q40 斑块的形成，作为亨廷顿氏病的模型。因此，这些数据支持尚未描述的 的抗衰老和抗氧化特性。还需要更多的研究来评估树皮对人类健康的真正益处及其毒理学特征。
