Hu Jiajie, Wang Joanne H, Wang Russel, Yu Xiong Bill, Liu Yunfeng, Baur Dale A
Department of Electrical Engineering and Computer Science, Case Western Reserve University School of Engineering, Cleveland, OH, 44106-7201, USA.
Department of Orthopedic Surgery, Case Medical Center, Cleveland, OH, 44106, USA.
3D Print Med. 2019 Mar 14;5(1):5. doi: 10.1186/s41205-019-0042-2.
Our long-term goal is to design and manufacture a customized graft with porous scaffold structure for repairing large mandibular defects using topological optimization and 3D printing technology. The purpose of this study is to characterize the mechanical behavior of 3D printed anisotropic scaffolds as bone analogs by fused deposition modeling (FDM).
Cone beam computed tomography (CBCT) images were used to reconstruct a 3D mandible and finite element models. A virtual sectioned-block of the mandible was used as the control group and the trabecular portion of the block was modified by topological optimization methods as experimental groups. FDM (FDM) printed samples at 0, 45 and 90 degrees with Poly-lactic acid (PLA) material under a three-point bending test. Finite element analysis was also used to validate the data obtained from the physical model tests.
The ultimate load, yield load, failure deflection, yield deflection, stress, strain distribution, and porosity of scaffold structures were compared. The results show that the topological optimized graft had the best mechanical properties.
The results from mechanical tests on physical models and numerical simulations from this study show a great potential for topological optimization and 3D printing technology to be served in design and rapidly manufacturing of artificial porous grafts.
我们的长期目标是利用拓扑优化和3D打印技术设计并制造一种具有多孔支架结构的定制移植物，用于修复大型下颌骨缺损。本研究的目的是通过熔融沉积建模（FDM）来表征3D打印各向异性支架作为骨模拟物的力学行为。
使用锥形束计算机断层扫描（CBCT）图像重建3D下颌骨和有限元模型。将下颌骨的虚拟切片块用作对照组，并通过拓扑优化方法对该块的小梁部分进行修改作为实验组。使用聚乳酸（PLA）材料在三点弯曲试验下以0、45和90度打印FDM样品。还使用有限元分析来验证从物理模型测试获得的数据。
比较了支架结构的极限载荷、屈服载荷、破坏挠度、屈服挠度、应力、应变分布和孔隙率。结果表明，拓扑优化后的移植物具有最佳的力学性能。
本研究中物理模型的力学测试结果和数值模拟结果表明，拓扑优化和3D打印技术在人工多孔移植物的设计和快速制造方面具有巨大潜力。
